Wake Forest Demon Deacons (2-1) vs. Louisville Cardinals (2-1) September 26, 2026 12:00 pm EDT The Line: Louisville Cardinals -13.5 / Wake Forest Demon Deacons 13.5; Over/Under: 57.5 (Get latest betting odds)
The Wake Forest Demon Deacons and Louisville Cardinals meet Saturday in week 4 college football action at L&N Federal Credit Union Stadium. Here’s a Louisville vs. Wake Forest Prediction. This article will include a Louisville vs. Wake Forest Pick.
The Wake Forest Demon Deacons beat Purdue, lost to Miami, and they play Stanford next. Wake Forest has won 6 of its last 8 games. Gio Lopez is completing 62.9 percent of his passes for 887 yards, 7 touchdowns, and 1 interception. Carlos Hernandez and Antonio Meeks have combined for 456 receiving yards and 3 touchdowns, while Jack Foley has 6 receptions.
The Wake Forest Demon Deacons ground game is averaging 137 yards per contest, and Ty Clark III leads the way with 144 yards and 1 touchdown. Defensively, Wake Forest is allowing 28.3 points and 379.3 yards per game. Vincent Firenze leads the Wake Forest Demon Deacons with 26 tackles, Langston Hardy has 2 sacks, and Davaughn Patterson has 3 pass deflections.
The Louisville Cardinals beat Villanova and SMU, and they play NC State next. Louisville has won 4 of its last 5 games. Lincoln Kienholz is completing 65.8 percent of his passes for 816 yards, 6 touchdowns, and 0 interceptions. Tre Richardson and Lawayne McCoy have combined for 469 receiving yards and 4 touchdowns, while Jaleel Skinner has 8 receptions.
The Louisville Cardinals’ ground game is averaging 229 yards per contest, and Keyjuan Brown leads the way with 231 yards and 2 touchdowns. Defensively, Louisville is allowing 28.3 points and 406.7 yards per game. Kaleb Beasley leads the Louisville Cardinals with 22 tackles, Clev Lubin has 1.5 sacks, and Stanquen Clark has 1 interception.
This could be a letdown spot for Louisville after a big game against SMU, but Wake Forest hasn’t played a lick of defense up to this point, and that’s concerning. Purdue, of all teams, lit up the Demon Deacons for 36 points and took them to double overtime. These playmakers for Louisville should have a field day, and I’m not sure Wake Forest has the horses to counter. Louisville is also 3-0 ATS on the season. I like the Cardinals by two touchdowns.