Oregon Ducks (1-0) vs. Oklahoma State Cowboys (0-1) September 12, 2026 12:00 pm EDT The Line: Oklahoma State Cowboys 1100 / Oregon Ducks -2100; Over/Under: 55.5 (Get latest betting odds)
In this article, we will formulate an Oregon vs Oklahoma State Prediction for this College Football Week 2 matchup on Saturday, September 12 th . Let’s take a look at the prediction for this College Football matchup.
The Oklahoma State Cowboys have a 0-1 record and are coming off a 10-24 road loss to Tulsa, where they were outgained 368-361 yards. Oklahoma State had 241 passing yards, 127 rushing yards, and 29/49 completed passes. They were 5/16 on third down conversions, had 6-59 penalties, and lost the turnover battle by 4-1.
Drew Mestemaker led Oklahoma State with 29/49 passes and 241 passing yards. Caleb Hawkins had a team-high 79 rushing yards, while Wyatt Young caught 8 passes for a team-high 84 receiving yards. Defensively, Ethan Wesloski led the Cowboys with 7 total tackles, 3 of them solo.
The Oregon Ducks have a 1-0 record and are coming off a 34-27 home win over Boise State, where they outgained them 497-274 yards. Oregon had 378 passing yards, 119 rushing yards, and 28/38 completed passes. They were 4/12 on third down conversions, had 10-90 penalties, and lost the turnover battle by 1-0.
Dante Moore led Oregon with 28/37 passes and 378 passing yards. Jordon Davison had a team-high 90 rushing yards, while Jeremiah McClellan caught 6 passes for a team-high 150 receiving yards. Defensively, Koi Perich led the Ducks with 11 total tackles, 3 of them solo, and Bear Alexander led the team with one sack.
In this Oregon vs Oklahoma State Prediction, Oregon is coming as -23.5 road favorites. Both teams are coming off opposite outcomes in their opening games of the season and Oklahoma State continued where they left off last season’s horrible 1-11 season (5-7 ATS), as they lost by scoring just 10 points. They will have to host the #4 projected team in the country this season in Oregon, who were undefeated on the road last season and were 9-6 against the spread. The difference here is huge and I will gladly lay the -23.5 points with Oregon on the road in this one.