Notre Dame Fighting Irish (3-0) vs. Purdue Boilermakers (1-2) September 26, 2026 2:00 pm EDT The Line: Purdue Boilermakers +28 / Notre Dame Fighting Irish -28; Over/Under: 58.5 (Get latest betting odds)
The Notre Dame Fighting Irish and the Purdue Boilermakers meet in week 4 college football action from Ross Ade Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Notre Dame Fighting Irish vs. Purdue Boilermakers Prediction.
The Notre Dame Fighting Irish come into this game looking to add on to a 27-10 win over Michigan State last time out to sit at 3-0 this season. After this game, Notre Dame will head on the road for a game against North Carolina.
CJ Carr has thrown for 726 yards, 6 touchdowns and 0 interceptions on 72.6% passing while Nolan James Jr. leads Notre Dame in rushing with 169 rushing yards and 3 touchdowns so far this season. Aneyas Williams sits behind James Jr. on the ground with 144 yards and 3 TDs. Micah Gilbert leads the Fighting Irish in receiving with 251 yards on 13 catches along with 1 touchdown, while Jordan Faison trails with 173 yards on 13 catches along with 2 touchdowns. On defense, Drayk Bowen has a team-high 19 total tackles, Boubacar Traore leads the team with 2 sacks, and Adon Shuler, Luke Talich, and Madden Faraimo have each recorded 1 interception. Notre Dame’s defense as a whole has combined for 7 sacks and 3 interceptions so far this season.
The Purdue Boilermakers come into this game looking to bounce back from a 52-38 loss at the hands of the UCLA Bruins last time out to sit at 1-2 this season. After this game, Purdue will head on the road for a game against Illinois.
Ryan Browne has thrown for 1,024 yards, 7 touchdowns and 1 interception on 73.3% passing while Fame Ijeboi leads Purdue in rushing with 248 rushing yards and 0 touchdowns so far this season. Travis Terrell Jr. sits behind Ijeboi on the ground with 43 yards and 0 TDs. Arzaad Waseem leads the Boilermakers in receiving with 321 yards on 20 catches along with 1 touchdown, while Xavier Townsend trails with 141 yards on 10 catches along with 2 touchdowns. On defense, John Slaughter has a team-high 22 total tackles, Demetrius Saunders has recorded 1 interception, and Purdue’s defense as a whole has combined for 6 sacks and 1 interception so far this season.
I’m on Purdue here. I get the case to be made for Notre Dame as the Irish historically have demolished Purdue with no regard for the Boilermakers. That being said, Purdue’s got something offensively here and this is a boatload of points for a Purdue team that went shot for shot with UCLA last week against a Notre Dame team that clearly doesn’t have the same punch as last season. Give me Purdue and the points.