San Diego Padres (17-8) vs. Arizona Diamondbacks (14-11) April 25, 2026 6:05 pm EDT The Line: Arizona Diamondbacks -118 / San Diego Padres -102; Over/Under: 15.5 (Get latest betting odds)
The San Diego Padres and the Arizona Diamondbacks meet Saturday in MLB action from Mexico City. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Arizona Diamondbacks prediction.
The San Diego Padres will send out German Marquez for the start here and Marquez is 2-1 with a 3.86 ERA and 15 strikeouts this season. In his last five starts against Arizona, Marquez is 1-1 with a 7.27 ERA and 17 strikeouts. Zac Gallen will start here and is 1-1 with a 3.51 ERA and 14 strikeouts this season. In his last five starts against the Padres, Gallen is 3-1 with a 3.10 ERA and 29 strikeouts.
The San Diego Padres come into this game looking to add on to their 10-8 win over Colorado from their last matchup to improve to 17-8 this season. After this series, the Padres will head home for a series against the Chicago Cubs.
Jackson Merrill has 20 hits with 6 doubles, 3 home runs and 14 RBIs while Ramon Laureano has 24 hits with 4 doubles, 2 triples, 4 home runs and 17 RBIs as well on the year. Fernando Tatis Jr. has 23 hits with 4 doubles and 12 RBIs and Xander Bogaerts has 26 hits with 2 doubles, 4 home runs and 16 RBIs. Manny Machado also has 16 hits with 2 doubles, 2 home runs and 11 RBIs as well on the year.
The Arizona Diamondbacks come into this game looking to shake off a 4-1 loss at the hands of the White Sox last time out to sit at 14-11 on the year. After this series, Arizona will head on the road for a series against the Milwaukee Brewers.
Corbin Carroll has 21 hits including 6 doubles, 3 triples, 3 home runs and a team-high 16 RBIs while Alek Thomas has logged 7 doubles with 8 RBIs as well this season. Ketel Marte has 19 hits with 2 doubles, 4 home runs and 9 RBIs and Geraldo Perdomo has 17 hits, with 3 doubles, a home run and 5 RBIs as well this season. Gabriel Moreno also has 11 hits with 5 doubles and Jose Fernandez has 19 hits with 2 home runs and 9 RBIs this season. Ildemaro Vargas also has 22 hits with 5 doubles, a triple, 3 home runs and 11 RBIs.
I’m on the over in this game. I just think these international series games have a tendency to be higher-scoring and with a highly questionable starting pitching matchup to go along with it, I don’t really see that changing here. These are two offenses that can put runs up as well so I’ll roll with the over in this one.