Houston Astros (6-3) vs. Oakland Athletics (2-6) April 5, 2026 4:05 pm EDT The Line: Oakland Athletics 104 / Houston Astros -126; Over/Under: 10 (Get latest betting odds)
In this article, we will formulate an Astros vs Athletics Prediction for this MLB matchup on Sunday, April 5 th in the fourth game of this series. Let’s take a look at the prediction for this MLB matchup.
The Athletics have a 2-6 record this season and are sitting in the last place of the AL West. They have a 1-1 home record and are coming off an 0-11 home loss against the Astros. Their previous three games were an 11-4 home win against the Astros, and a 1-5 road loss and a 5-2 road win against the Braves.
The Athletics have a .201 batting average this season, .262 OBP and .326 Slugging percentage. Oakland’s pitching staff has a 5.14 ERA and 1.73 WHIP. Shea Langeliers is the team’s best hitter with a .300 batting average, also leading the team in RBI with 8 and adding a team-high five home runs.
Jacob Lopez (L) is the projected starting pitcher for the Athletics, and he has a 0-1 record, 6.75 ERA and 2.75 WHIP.
The Houston Astros have a 6-3 record this season and are sitting in the first place of the AL West. They have a 1-1 road record and are coming off an 11-0 road win against the Athletics. Their previous three games were a 4-11 road loss against the Athletics, and a 6-4 home win and a 9-2 home win against the Red Sox.
The Astros have a .283 batting average this season, .391 OBP and .479 Slugging percentage. Houston’s pitching staff has a 4.84 ERA and 1.40 WHIP. Yordan Alvarez is the team’s best hitter with a .423 batting average, also leading the team in RBI with 8 and adding a team-high three home runs. Christian Walker adds 9 RBI.
Lance McCullers Jr. (R) is the projected starting pitcher for the Astros, and he has a 1-0 record, 1.29 ERA and 0.71 WHIP.
The Athletics are 8-2 in their last 10 meetings against the Astros and are 4-2 in their last 6 home meetings.
In this Astros vs Athletics Prediction, the Astros are coming as -125 road favorites. The Astros bounced back yesterday with a dominating 11-0 shutout win and are now putting Lance McCullers Jr. on the mound, who is coming off a quality start in his first game of the season, after having a disastrous 2025 campaign. Jacob Lopez is coming off a shaky start for the A’s, who have been inferior offensively and even weaker against right-handed pitching, with just 2.9 runs/9. Take the Astros to win this one in a very good price.