Houston Astros (22-31) vs. Chicago Cubs (29-23) May 24, 2026 2:20 pm EDT The Line: Chicago Cubs -179 / Houston Astros 147; Over/Under: 7 (Get latest betting odds)
In this article, we will formulate an Astros vs Cubs Prediction for this MLB matchup on Sunday, May 24 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Chicago Cubs have a 29-23 record this season and are sitting in the third place of the NL Central. They have a 18-10 home record and are coming off a 0-3 home defeat against the Astros. They will face the Pirates and the Cardinals next.
The Cubs have a .238 batting average this season, .335 OBP and .390 Slugging percentage. Chicago’s pitching staff has a 4.05 ERA and 1.23 WHIP. Nico Hoerner is the team’s best hitter with a .256 batting average, also leading the team in RBI with 30. Ian Happ adds a team-high 10 home runs.
Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 4-4 record, 3.38 ERA and 1.04 WHIP.
The Houston Astros have a 22-31 record this season and are sitting in the fourth place of the AL West. They have a 10-17 away record and are coming off a 3-0 road win against the Cubs. They will face the Rangers and the Brewers next.
The Astros have a .246 batting average this season, .320 OBP and .403 Slugging percentage. Houston’s pitching staff has a 5.18 ERA and 1.50 WHIP. Yordan Alvarez is the team’s best hitter with a .300 batting average, also adding a team-high 15 home runs. Christian Walker leads the team in RBI with 34.
Peter Lambert (R) is the projected starting pitcher for the Astros, and he has a 2-4 record, 3.57 ERA and 1.08 WHIP.
The Astros are 4-1 in their last 5 meetings against the Cubs but are 2-3 in their last 5 visits in Chicago. Under is 6-2 in their last 8 meetings.
In this Astros vs Cubs Prediction, the Cubs are coming as -180 home favorites. The Cubs have been arguably the worst team in baseball in the past week or so, having lost seven straight games and have scored just four runs in their last four games, but they are being -180 home favorites today for some reason. The market still has not adjusted and Imanaga is coming off his worst start of the season and has been slightly weaker at home. Take the Astros and the nice plus money in this one.