Houston Astros (16-24) vs. Cincinnati Reds (21-19) May 10, 2026 1:40 pm EDT The Line: Cincinnati Reds -126 / Houston Astros 104; Over/Under: 9 (Get latest betting odds)
In this article, we will formulate an Astros vs Reds Prediction for this MLB matchup on Sunday, May 10 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Cincinnati Reds have a 21-19 record this season and are sitting in the fifth place of the NL Central. They have a 11-9 home record and are coming off a 3-1 win at home against the Astros. They will face the Nationals and the Guardians next.
The Reds have a .218 batting average this season, .303 OBP and .378 Slugging percentage. Cincinnati’s pitching staff has a 4.63 ERA and 1.49 WHIP. Elly De La Cruz is the team’s best hitter with a .277 batting average, also leading the team in RBI with 29. Sal Stewart adds a team‑high 10 home runs.
Andrew Abbott (L) is the projected starting pitcher for the Reds, and he has a 1-2 record, 5.13 ERA and 1.64 WHIP.
The Houston Astros have a 16-24 record this season and are sitting in the fourth place of the AL West. They have a 7-14 away record and are coming off a 1-3 loss on the road against the Reds. They will face the Mariners and the Rangers next.
The Astros have a .261 batting average this season, .337 OBP and .436 Slugging percentage. Houston’s pitching staff has a 5.56 ERA and 1.59 WHIP. Yordan Alvarez is the team’s best hitter with a .327 batting average, also adding a team‑high 13 home runs. Christian Walker leads the team in RBI with 27.
Kai-Wei Teng (R) is the projected starting pitcher for the Astros, and he has a 1-2 record, 2.35 ERA and 0.96 WHIP.
The Reds are 7-3 in their last 10 meetings against the Astros and are 4-1 in their last 5 meetings in Cincinnati.
In this Astros vs Reds Prediction, the Reds are coming as -125 home favorites. The Reds finally ended a lengthy winning streak yesterday and I like them today as well, as Andrew Abbott is coming off a shutout win and I don’t trust Kai-Wei Teng for the Astros, who also have the league’s worst bullpen to come after him. On top of that, Houston is weaker against left-handed pitching, so everything points towards another Reds win in this matchup.