San Francisco Giants (6-9) vs. Baltimore Orioles (7-7) April 12, 2026 1:35 pm EDT The Line: Baltimore Orioles -125 / San Francisco Giants +105; Over/Under: 8.5 (Get latest betting odds)
The San Francisco Giants and the Baltimore Orioles meet Tuesday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Baltimore Orioles prediction.
The San Francisco Giants will send out Adrian Houser for the start here and Houser is 0-1 with a 3.97 ERA and 7 strikeouts this season. In his career, Houser is 0-2 with a 4.50 ERA and 9 strikeouts against the Orioles. Cade Povich will start here for the Orioles and is 0-0 with a 3.18 ERA and 2 strikeouts this season. This will be Povich’s first career start against the Giants.
The San Francisco Giants come into this game looking to bounce back from a 6-2 loss at the hands of Baltimore on Saturday to sit at 6-9 this season. After this series, the Giants will head on the road for a series against the Cincinnati Reds.
Luis Arraez has a team-high 17 hits with a double, 2 triples and 6 RBIs while Willy Adames has 15 hits with 8 doubles, 2 home runs and 5 RBIs. Matt Chapman has a home run and 7 RBIs and Harrison Bader has a home run and 3 RBIs while Jung Hoo Lee has 10 hits with 4 doubles and a team-high 7 RBIs. Heliot Ramos has 12 hits with a double and 6 RBIs but also has a team-high 21 strikeouts this season. Rafael Devers also has 13 hits with a double, 2 home runs and 6 RBIs.
The Baltimore Orioles come into this game looking to build on their 6-2 win over San Francisco last time out to improve to 7-7 this season. After this series, the Orioles will take on the Arizona Diamondbacks in a series at home.
Taylor Ward has 19 hits with 10 doubles and 8 RBIs while Gunnar Henderson has 14 hits with 3 doubles, 6 home runs and 12 RBIs while Pete Alonso has 9 hits with 2 doubles, a home run and 3 RBIs. Adley Rutschman has 10 hits with 6 doubles and 3 RBIs. Jeremiah Jackson has 10 hits with a double, a home run and 6 RBIs while Dylan Beavers also has 9 hits with a double, a home run and 5 RBIs.
I’m on the Orioles here. I just think that this is a favorable matchup for Baltimore as I still don’t trust the Giants against a lefty and Cade Povich is one of the better arms in this Oriole rotation while I think the Baltimore bats are waking up and will get to Adrian Houser who is still one of the weaker links of this Giants rotation. Give me Baltimore.