Toronto Blue Jays (38-39) vs. Chicago Cubs (40-37) June 21, 2026 2:20 pm EDT The Line: Chicago Cubs 101 / Toronto Blue Jays -122; Over/Under: 6.5 (Get latest betting odds)
In this article, we will formulate a Blue Jays vs Cubs Prediction for this MLB matchup on Sunday, June 21 st in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Chicago Cubs have a 40-37 record this season and are sitting in the 3rd place of the NL Central. They have a 23-17 home record and are coming off a 6-8 home defeat against the Blue Jays. They will face the Mets and the Brewers next.
The Cubs have a .244 batting average this season, .337 OBP and .401 Slugging percentage. Chicago’s pitching staff has a 4.28 ERA and 1.24 WHIP. Pete Crow-Armstrong is the team’s best hitter with a .286 batting average. Michael Busch leads the team in RBI with 42, while Ian Happ adds a team-high 16 home runs.
Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 4-6 record, 4.26 ERA and 1.06 WHIP.
The Toronto Blue Jays have a 38-39 record this season and are sitting in the 3rd place of the AL East. They have a 17-21 road record and are coming off an 8-6 road win against the Cubs. They will face the Astros and the Rangers next.
The Blue Jays have a .249 batting average this season, .311 OBP and .391 Slugging percentage. Toronto’s pitching staff has a 4.13 ERA and 1.31 WHIP. Ernie Clement is the team’s best hitter with a .292 batting average. Kazuma Okamoto leads the team in RBI with 45, adding a team-high 16 home runs.
Dylan Cease (R) is the projected starting pitcher for the Blue Jays, and he has a 4-3 record, 2.71 ERA and 1.19 WHIP.
The Jays are 4-2 in their last 6 meetings against the Cubs and have won two of their last three visits in Chicago.
In this Blue Jays vs Cubs Prediction, the Blue Jays are coming as -130 road favorites. The Jays are being favorited in Chicago even though they lost in the opening game of this series by 2-16 and are facing a leftie in Imanaga. I will gladly take the plus money with the home team, as Imanaga has bounced back and has one earned run in his last two starts, the Cubs have a slightly better bullpen and a superior offense, with the Jays being weaker against southpaws. Take the Cubs to win.