Minnesota Twins (23-27) vs. Boston Red Sox (22-27) May 22, 2026 7:10 pm EDT The Line: Boston Red Sox -157 / Minnesota Twins +130; Over/Under: 7.5 (Get latest betting odds)
The Minnesota Twins and the Boston Red Sox meet Friday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Boston Red Sox prediction.
The Minnesota Twins will send out Connor Prielipp for the start in this one and Prielipp is 1-2 with a 2.88 ERA and 29 strikeouts this season. This will be Prielipp’s first career start against the Red Sox. Payton Tolle will start for the Red Sox here and is 2-2 with a 2.05 ERA and 30 strikeouts this season. This will be Tolle’s first career start against the Twins.
The Minnesota Twins come into this game looking to build on their 4-1 win over the Houston Astros last time out to improve to 23-27 this season. After this series, the Twins will head on the road for a series against the Chicago White Sox.
Byron Buxton has 46 hits with 9 doubles, a triple, 15 home runs and 23 RBIs while Josh Bell’s added 40 hits with 8 doubles, 5 home runs and 29 RBIs. Luke Keaschall has 39 hits with 8 doubles, a homer and 17 RBIs and Matt Wallner has 20 hits with 3 doubles, 4 home runs and 10 RBIs. Brooks Lee has 5 home runs with 24 RBIs and Victor Caratini has 16 RBIs while Ryan Jeffers has 36 hits with 6 doubles, a triple, 7 home runs and 26 RBIs this season.
The Boston Red Sox come into this game looking to add on to their 4-3 win over the Kansas City Royals last time out to improve to 22-27 this season. After this series, the Red Sox will take on the Atlanta Braves at home.
Wilyer Abreu leads the Red Sox with 534 hits including 7 doubles, a triple, 6 home runs and 19 RBIs while Trevor Story has 34 hits with 7 doubles, 3 homers and 19 RBIs and Marcelo Mayer’s added 29 hits with 6 doubles, 2 home runs and 9 RBIs as well. Roman Anthony has 25 hits with 5 doubles, a triple, a home run and 5 RBIs so far this season while Jarren Duran has 34 hits with 9 doubles, 6 home runs and 24 RBIs as well this season. Willson Contreras has added 45 hits with 6 doubles, 10 homers and 30 RBIs of his own on the year.
I’m on the Red Sox in this one. I don’t really trust either one of these teams against a lefty, so Prielipp and Tolle should be in a good spot here, but I trust the Red Sox’s bullpen a lot more than I trust Minnesota’s in this spot and I think the Red Sox take care of business at home here. Give me the Red Sox.