NY Yankees (13-9) vs. Boston Red Sox (9-13) April 21, 2026 6:45 pm EDT The Line: Boston Red Sox -108 / NY Yankees -112; Over/Under: 8.5 (Get latest betting odds)
The New York Yankees and the Boston Red Sox meet Tuesday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Yankees vs. Boston Red Sox prediction.
The New York Yankees will send out Luis Gil here and Gil is 0-1 with a 7.00 ERA and 7 strikeouts this season. In his last five starts against Boston, Gil is 2-1 with a 0.99 ERA and 26 strikeouts. Connelly Early will start this one for Boston and is 1-0 with a 2.29 ERA and 20 strikeouts this season. This will be Early’s first career start against the Yankees.
The New York Yankees come into this game looking to build on their 7-0 win over the Royals last time out to sit at 13-9 this season. After this series, the Yankees will head on the road again for a series against the Houston Astros.
Giancarlo Stanton has 18 hits with 3 doubles, 2 home runs and 10 RBIs while Ben Rice has 22 hits with 6 doubles, 8 home runs and 18 RBIs and Aaron Judge has 19 hits with 3 doubles, 9 home runs and 16 RBIs. Cody Bellinger also has 21 hits with 3 doubles, a triple, 3 home runs and 11 RBIs. Jazz Chisholm Jr. also has 12 hits with 5 doubles as well on the year.
The Boston Red Sox come into this game looking to add on to their 8-6 win over Detroit last time out to sit at 9-13 this season. After this series, the Red Sox will head on the road for a series against the Baltimore Orioles.
Wilyer Abreu leads the Red Sox with 24 hits including 4 doubles, a triple, 3 home runs and 11 RBIs while Trevor Story has 18 hits with 5 doubles, 2 homers and 17 RBIs and Marcelo Mayer’s added 10 hits with 3 doubles, a home run and 3 RBIs as well. Roman Anthony has 18 hits with 3 doubles, a triple, a home run and 4 RBIs so far this season while Jarren Duran has 11 hits with 3 doubles, a home run and 10 RBIs as well this season. Willson Contreras has added 20 hits with 2 doubles, 4 homers and 12 RBIs of his own on the year.
I’m on the Boston Red Sox here. I just think that this is the best rivalry in baseball, and the Red Sox, no matter how bad they may be in a certain season, will always give the Yankees their best and get a matchup with Gil, who I’m still not sold on this season. On the flipside, New York’s going against Early here and the Yankees haven’t been overly convincing against lefties for a good chunk of the year so far and I think the Red Sox take advantage here. Give me Boston.