St. Louis Cardinals (77-82) vs. Milwaukee Brewers (100-59) September 25, 2026 7:40 pm EDT The Line: Milwaukee Brewers -184 / St. Louis Cardinals 151; Over/Under: 8 (Get latest betting odds)
In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB matchup on Friday, September 25 th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The Milwaukee Brewers have a 100-59 record this season and are sitting in the 1st place of the NL Central. They have a 52-26 home record and are coming off a 5-1 road win against the Phillies.
The Milwaukee Brewers have a .258 batting average this season, .340 OBP and .402 Slugging percentage. Milwaukee’s pitching staff has a 3.52 ERA and 1.19 WHIP. Jackson Chourio is the team’s best hitter with a .285 batting average. Brice Turang leads the team in RBI with 94, while Jake Bauers adds a team-high 26 home runs.
Robert Gasser (L) is the projected starting pitcher for the Brewers, and he has a 5-5 record, 4.01 ERA and 1.24 WHIP.
The St. Louis Cardinals have a 77-82 record this season and are sitting in the 4th place of the NL Central. They have a 39-39 away record and are coming off a 1-2 road loss against the Pirates.
The St. Louis Cardinals have a .241 batting average this season, .314 OBP and .379 Slugging percentage. St. Louis’s pitching staff has a 4.24 ERA and 1.35 WHIP. Alec Burleson is the team’s best hitter with a .279 batting average, leading the team in RBI with 113, while Jordan Walker adds a team-high 28 home runs.
Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 7-9 record, 3.84 ERA and 1.25 WHIP.
The Brewers are 8-1 in their last 9 meetings against the Cardinals and have won their last three meetings in Milwaukee.
In this Cardinals vs Brewers Prediction, the Brewers are coming as -175 home favorites. Both teams have nothing to play for, so I will target the total in this game. Both pitchers have been in good form and both bullpens in excellent shape. Both teams have been playing lower-scoring games lately, as they are 8-1 to the under in their last 9 games combined, so I expect another low-scoring affair today. Take the under 8 runs.