St. Louis Cardinals (47-39) vs. Chicago Cubs (49-40) July 5, 2026 2:30 pm EDT The Line: Chicago Cubs -157 / St. Louis Cardinals 130; Over/Under: 8 (Get latest betting odds)
In this article, we will formulate a Cardinals vs Cubs Prediction for this MLB matchup on Sunday, July 5 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Chicago Cubs have a 49‑40 record this season and are sitting in the 2nd place of the NL Central. They have a 26‑19 home record and are coming off a 0‑3 home defeat against the Cardinals. They will face the Orioles and the Reds next.
The Cubs have a .244 batting average this season, .338 OBP and .411 Slugging percentage. Chicago’s pitching staff has a 4.36 ERA and 1.27 WHIP. Pete Crow‑Armstrong is the team’s best hitter with a .289 batting average, adding a team‑high 19 home runs. Dansby Swanson leads the team in RBI with 57.
Javier Assad (R) is the projected starting pitcher for the Cubs, and he has a 6‑1 record, 4.53 ERA and 1.12 WHIP.
The St. Louis Cardinals have a 47‑39 record this season and are sitting in the 3rd place of the NL Central. They have a 24‑18 road record and are coming off a 3‑0 road win against the Cubs. They will face the Brewers and the Braves next.
The Cardinals have a .248 batting average this season, .325 OBP and .397 Slugging percentage. St. Louis’ pitching staff has a 4.14 ERA and 1.33 WHIP. Jordan Walker is the team’s best hitter with a .291 batting average, adding a team‑high 19 home runs. Alec Burleson leads the team in RBI with 63.
Matthew Liberatore (L) is the projected starting pitcher for the Cardinals, and he has a 4‑5 record, 5.33 ERA and 1.55 WHIP.
The Cardinals are 4-1 in their last 5 meetings against the Cubs and have won their last two visits in Chicago.
In this Cardinals vs Cubs Prediction, the Cubs are coming as -150 home favorites. The Cubs have been atrocious in this series, having lost both games with a combined 20-1 score but I like them to bounce back today as Javier Assad goes up against a struggling Matthew Liberatore. Liberatore has been in very bad form with a 9.00 ERA across his last three starts and has a 5.45 road ERA, while the Cubs have a better offense, are better against lefties and also have a better bullpen. Take the Cubs to win.