St. Louis Cardinals (14-9) vs. Miami Marlins (11-13) April 22, 2026 12:10 pm EDT The Line: Miami Marlins 0.0001 / St. Louis Cardinals 0.0001; Over/Under: 0.0001 (Get latest betting odds)
In this article, we will formulate a Cardinals vs Marlins Prediction for this MLB matchup on Wednesday, April 22 nd in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Miami Marlins have a 11-13 record this season and are sitting in the second place of the NL East. They have a 9-6 home record and are coming off a 3-5 home loss against the Cardinals. Their previous three games were a 5-3 home win against the Cardinals, a 5-3 home win, and a 2-5 home loss against the Brewers.
The Marlins have a .253 batting average this season, .331 OBP and .388 Slugging percentage. Miami’s pitching staff has a 4.05 ERA and 1.26 WHIP. Xavier Edwards is the team’s best hitter with a .348 batting average. Liam Hicks leads the team in RBI with 21, also adding a team‑high 4 home runs.
Janson Junk (R) is the projected starting pitcher for the Marlins, and he has a 0-2 record, 4.50 ERA and 1.32 WHIP.
The St. Louis Cardinals have a 14-9 record this season and are sitting in the third place of the NL Central. They have a 7-4 away record and are coming off a 5-3 road win against the Marlins. Their previous three games were a 3-5 road loss against the Marlins, and a 7-5 and a 7-5 road win against the Astros.
The Cardinals have a .232 batting average this season, .325 OBP and .377 Slugging percentage. St. Louis’ pitching staff has a 4.78 ERA and 1.41 WHIP. Jordan Walker is the team’s best hitter with a .292 batting average, also leading the team in RBI with 16. Alec Burleson adds a team‑high 3 home runs.
Kyle Leahy (R) is the projected starting pitcher for the Cardinals, and he has a 2-2 record, 5.21 ERA and 1.53 WHIP.
Both teams are tied 4-4 in their last 8 meetings and are 2-2 in their last 4 meetings in Miami.
In this Cardinals vs Marlins Prediction, the Marlins are coming as -135 home favorites. Both teams have split wins in this series and I don’t trust either pitcher in this matchup, as they both have a 9.71 ERA combined. Both teams are slightly better against righties, with 10 runs/9 combined against right-handed pitching and are 12-6-1 to the over in their last 19 games combined. Take the over 8.5 runs in this one.