St. Louis Cardinals (6-5) vs. Washington Nationals (4-7) April 8, 2026 4:05 pm EDT The Line: Washington Nationals 104 / St. Louis Cardinals -126; Over/Under: 8.5 (Get latest betting odds)
In this article, we will formulate a Cardinals vs Nationals Prediction for this MLB matchup on Wednesday, April 8 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Washington Nationals have a 4-7 record this season and are sitting in the fifth place of the NL East. They have a 1-4 home record and are coming off a 6-7 home loss against the Cardinals. Their previous three games were a 9-6 home win against the Cardinals, a 6-8 and a 5-10 home loss against the Dodgers.
The Nationals have a .276 batting average this season, .351 OBP and .453 Slugging percentage. Washington’s pitching staff has a 6.06 ERA and 1.65 WHIP. Brady House is the team’s best hitter with a .317 batting average. CJ Abrams leads the team in RBI with 14, also adding a team-high 4 home runs.
Miles Mikolas (R) is the projected starting pitcher for the Nationals, and he has a 0-2 record, 14.46 ERA and 2.25 WHIP.
The St. Louis Cardinals have a 6-5 record this season and are sitting in the fourth place of the NL Central. They have a 2-3 away record and are coming off a 7-6 road win against the Nationals. Their previous three games were a 6-9 road loss against the Nationals, a 5-3 road win, and a 6-11 road loss against the Tigers.
The Cardinals have a .225 batting average this season, .318 OBP and .364 Slugging percentage. St. Louis’ pitching staff has a 5.31 ERA and 1.61 WHIP. Jordan Walker is the team’s best hitter with a .300 batting average, also leading the team in RBI with 11 and adding a team-high 4 home runs.
Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 0-1 record, 2.53 ERA and 0.84 WHIP.
The Cardinals are 7-2 in their last 9 meetings against the Nationals and are 4-1 in their last 5 visits in Washington.
In this Cardinals vs Nationals Prediction, the Cardinals are coming as -125 road favorites. The Nationals have been struggling mightily lately, having just one win in their last seven games and they have allowed 6+ runs in their last six games. Mikolas has looked terrible in his two starts this season with 15 earned runs and the Nationals also have the 28 th bullen in baseball to follow him, so I just have to look at the Cardinals in this one to take care of business on the road in a nice price.