St. Louis Cardinals (5-4) vs. Washington Nationals (3-6) April 6, 2026 6:45 pm EDT The Line: Washington Nationals -102 / St. Louis Cardinals -118; Over/Under: 8 (Get latest betting odds)
In this article, we will formulate a Cardinals vs Nationals Prediction for this MLB matchup on Monday, April 6 th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The Washington Nationals have a 3-6 record this season and are sitting in the last place of the NL East. They have a 0-3 home record and are coming off an 8-6 home loss against the Dodgers . Their previous three games were a 5-10 home loss and a 6-13 home loss against the Dodgers, and a 5-6 road loss against the Phillies.
The Nationals have a .270 batting average this season, .340 OBP and .429 Slugging percentage. Washington’s pitching staff has a 6.27 ERA and 1.61 WHIP. Luis Garcia Jr. is the team’s best hitter with a .324 batting average. CJ Abrams leads the team in RBI with 12, also adding a team-high three home runs.
Zack Littell (R) is the projected starting pitcher for the Nationals, and he has a 0-1 record, 5.40 ERA and 1.60 WHIP.
The St. Louis Cardinals have a 5-4 record this season and are sitting in the fourth place of the NL Central. They have a 1-2 road record and are coming off a 5-3 road win against the Tigers. Their previous three games were a 6-11 road loss and a 0-4 road loss against the Tigers, and a 2-1 home win against the Mets.
The Cardinals have a .217 batting average this season, .294 OBP and .336 Slugging percentage. St. Louis’ pitching staff has a 4.94 ERA and 1.56 WHIP. Victor Scott II is the team’s best hitter with a .310 batting average. Jordan Walker leads the team in RBI with 8, and Nolan Gorman adds a team-high two home runs.
Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 1-0 record, 0.00 ERA and 1.20 WHIP.
The Cardinals are 6-1 in their last 7 meetings against the Nationals, having swept their last series in Washington last season by 3-0 wins.
In this Cardinals vs Nationals Prediction, the Cardinals are coming as -120 road favorites. The Nationals are on a free fall with five consecutive losses and got 31 earned runs in three games against the Dodgers. They are facing a Cardinals squad that has scored 11 runs in its last two games and put Pallante on the mound who his first start of the season was a shutout. On the flip side, Littell was torched by the Nats last season, with 7 earned runs in two starts and Washington has the 5 th -worse bullpen ERA in baseball to back him up, so I like the value with Saint Louis in this one. Take the Cardinals on the moneyline.