St. Louis Cardinals (29-22) vs. Cincinnati Reds (27-25) May 24, 2026 1:40 pm EDT The Line: Cincinnati Reds -122 / St. Louis Cardinals 101; Over/Under: 9.5 (Get latest betting odds)
In this article, we will formulate a Cardinals vs Reds Prediction for this MLB matchup on Sunday, May 24 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Cincinnati Reds have a 27-25 record this season and are sitting in the fourth place of the NL Central. They have a 14-12 home record and are coming off a 7-6 home win against the Cardinals. They will face the Mets and the Braves next.
The Reds have a .227 batting average this season, .310 OBP and .393 Slugging percentage. Cincinnati’s pitching staff has a 4.78 ERA and 1.47 WHIP. Elly De La Cruz is the team’s best hitter with a .288 batting average, also leading the team in RBI with 35 and adding a team-high 12 home runs.
Brady Singer (R) is the projected starting pitcher for the Reds, and he has a 2-4 record, 6.26 ERA and 1.70 WHIP.
The St. Louis Cardinals have a 29-22 record this season and are sitting in the second place of the NL Central. They have a 16-9 away record and are coming off a 6-7 road defeat against the Reds. They will face the Brewers and the Cubs next.
The Cardinals have a .242 batting average this season, .323 OBP and .393 Slugging percentage. St. Louis’ pitching staff has a 4.20 ERA and 1.37 WHIP. Jordan Walker is the team’s best hitter with a .302 batting average, also leading the team in RBI with 42 and adding a team-high 15 home runs.
Matthew Liberatore (L) is the projected starting pitcher for the Cardinals, and he has a 2-2 record, 4.70 ERA and 1.55 WHIP.
Both teams are tied 5-5 in their last 10 meetings and are 2-2 in their last 4 meetings in Cincinnati.
In this Cardinals vs Reds Prediction, the Reds are coming as -120 home favorites. I don’t like either pitching in this matchup, as they both have a combined 10.96 ERA and both games in this series have been high-scoring ones. Liberatore has given up 8 runs across his last two starts and Singer has given up 16 runs across his last four and the Reds are better against righties and have a bad bullpen that ranks 28 th in baseball. Take the over 9.5 runs in this one.