St. Louis Cardinals (28-21) vs. Cincinnati Reds (26-24) May 22, 2026 6:40 pm EDT The Line: Cincinnati Reds -110 / St. Louis Cardinals -109; Over/Under: 9.5 (Get latest betting odds)
In this article, we will formulate a Cardinals vs Reds Prediction for this MLB matchup on Friday, May 22 nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The Cincinnati Reds have a 26-24 record this season and are sitting in the fifth place of the NL Central. They have a 13-11 home record and are coming off a 9-4 win against the Phillies. They will face the Mets and the Braves next.
The Reds have a .229 batting average this season, .312 OBP and .394 Slugging percentage. Cincinnati’s pitching staff has a 4.71 ERA and 1.46 WHIP. Elly De La Cruz is the team’s best hitter with a .290 batting average. Sal Stewart leads the team in RBI with 34, adding a team-high 12 home runs.
Chris Paddack (R) is the projected starting pitcher for the Reds, and he has a 0-5 record, 7.07 ERA and 1.63 WHIP.
The St. Louis Cardinals have a 28-21 record this season and are sitting in the third place of the NL Central. They have a 15-8 away record and are coming off a 6-2 loss against the Pirates. They will face the Brewers and the Cubs next.
The Cardinals have a .240 batting average this season, .320 OBP and .389 Slugging percentage. St. Louis’ pitching staff has a 4.24 ERA and 1.38 WHIP. Jordan Walker is the team’s best hitter with a .295 batting average, also leading the team in RBI with 35 and a team-high 13 home runs.
Kyle Leahy (R) is the projected starting pitcher for the Cardinals, and he has a 5-3 record, 3.94 ERA and 1.55 WHIP.
The Reds are 3-1 in their last 4 meetings against the Cardinals but are 1-2 in their last three visits in Cincinnati.
In this Cardinals vs Reds Prediction, both teams are coming at a pickem price. The Cardinals have the pitching edge as Kyle Leahy goes up against a struggling Chris Paddack. Leahey has just two earned runs across his last three starts, while Paddack has been atrocious at home with a 15.88 home ERA and was torched in his previous start against the Cardinals this season with 5 earned runs. Take the Cardinals to win this one on the road.