Chicago White Sox (75-71) vs. St. Louis Cardinals (72-75) September 11, 2026 8:15 pm EDT The Line: St. Louis Cardinals -107 / Chicago White Sox -112; Over/Under: 8.5 (Get latest betting odds)
In this article we will formulate a Cardinals vs White Sox prediction for this MLB game on Friday, September 11th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.
The St. Louis Cardinals are 72-75 this year after they lost all three against the Giants by scores of 4-5, 1-2, and 6-7. In game three, St. Louis led 6-1 in the eighth inning, but they allowed six runs in the bottom of the eighth for the loss. The Cardinals recorded eight hits in the game and they were led by Bernal, who went 1-4 with one home run and three RBIs. Pallante allowed five hits and one earned run over 5.0 innings, while Soriano blew the save and picked up the loss. Prior to that series, St. Louis won two out of three against the Rockies and two out of three against the Dodgers.
This season, St. Louis has a 4.31 ERA with a 1.35 WHIP and a .255 opponent batting average, while they have scored 668 runs with a .243 batting average and a .317 on base percentage. Jordan Walker has led the Cardinals with 28 home runs and 100 RBIs, while Alec Burleson has added 22 home runs and 104 RBIs. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 5-14 with a 5.57 ERA and a 1.47 WHIP over 139.0 innings pitched this year.
The Chicago White Sox are 75-71 this season after they lost all three against the Pirates by scores of 3-9, 2-4, and 0-2. In game three, Chicago allowed a run in the fourth inning and another in the eighth in the low scoring loss. The White Sox recorded two hits and they were led by Grichuk, who went 1-1 in the game. Smith opened the game, while Fedde allowed two earned runs for the loss. Prior to that series, Chicago won two out of three against the Twins, but lost three out of four against the Astros before that.
This season, Chicago has a 4.13 ERA with a 1.31 WHIP and a .241 opponent batting average, while they have scored 685 runs with a .235 batting average and a .317 on base percentage. Colson Montgomery has led the White Sox with 31 home runs and 83 RBIs, while Miguel Vargas has added 30 home runs and 79 RBIs. The projected starting pitcher for Chicago is Anthony Kay, who is 9-8 with a 4.47 ERA and a 1.36 WHIP over 141.0 innings pitched this season.
St. Louis comes into this matchup after getting swept by the Giants and they had a horrible collapse in game three. The Cardinals are 34-38 at home this year, while the White Sox are 32-40 on the road. Chicago was also swept in their last series by the Pirates and they scored just five runs in those three games. The Sox are starting Kay, who has allowed 4+ earned runs in three straight starts, while Liberatore has allowed 5, 3, 8, and 3 earned runs in his last four starts. Take the over here.