Chicago White Sox (76-72) vs. St. Louis Cardinals (73-76) September 13, 2026 2:15 pm EDT The Line: St. Louis Cardinals / Chicago White Sox ; Over/Under: (Get latest betting odds)
In this article we will formulate a Cardinals vs White Sox prediction for this MLB game on Sunday, September 13th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.
The St. Louis Cardinals are 73-76 this season after they split the first two games by scores of 7-3 and 5-6. In game two, St. Louis led 5-4 in the ninth inning, but they allowed two in the ninth for the loss. The Cardinals recorded eight hits and they committed one error in the game, while they were led by Winn, who went 2-4 with two RBIs. Leahy allowed two hits and zero earned runs over 3.0 innings, while O’Brien blew the save and picked up the loss. Prior to this series, St. Louis lost all three against the Giants, but did win two out of three against the Rockies before that.
This season, St. Louis has a 4.31 ERA with a 1.35 WHIP and a .254 opponent batting average, while they have scored 680 runs with a .244 batting average and a .317 on base percentage. Jordan Walker has led the Cardinals with 28 home runs and 100 RBIs, while Alec Burleson has added 22 home runs and 106 RBIs. The projected starting pitcher for St. Louis is Michael McGreevy, who is 6-9 with a 3.92 ERA and a 1.25 WHIP over 154.0 innings pitched this season.
The Chicago White Sox are 76-72 this year after they won game two by a score of 6-5 last night. Chicago erased a 4-1 deficit in the fifth inning and they hit the winning home run with two outs in the ninth for the victory. The White Sox recorded six hits and they committed two errors in the game, while they were led by Grichuk, who went 1-4 with one home run and two RBIs. Newcomb opened the game, while Hicks got the win and Hudson picked up the save. Prior to this series, Chicago lost all three against the Pirates, but did win two out of three against the Twins before that.
This season, Chicago has a 4.16 ERA with a 1.31 WHIP and a .242 opponent batting average, while they have scored 694 runs with a .235 batting average and a .319 on base percentage. Colson Montgomery has led the White Sox with 31 home runs and 84 RBIs, while Miguel Vargas has added 30 home runs and 79 RBIs. The projected starting pitcher for Chicago is Sean Burke, who is 8-7 with a 3.58 ERA and a 1.20 WHIP over 156.0 innings pitched this year.
St. Louis comes into this matchup after a terrible loss on Saturday night and they have dropped four of their last five. The Cardinals are 35-39 at home this year, while the White Sox are 33-41 on the road. Chicago has also lost four of their last five games and they have scored three or fewer in all four losses. The White Sox are starting Burke, who has allowed 7, 0, 2, 4, and 4 earned runs in his last five starts, while McGreevy has allowed 2, 4, 7, and 3 earned runs in his last four outings. Take the over here.