Cleveland Guardians (41-39) vs. Chicago White Sox (41-37) June 24, 2026 2:10 pm EDT The Line: Chicago White Sox -105 / Cleveland Guardians -115; Over/Under: 8.5 (Get latest betting odds)
The Cleveland Guardians and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Chicago White Sox prediction.
The Cleveland Guardians will send out Tanner Bibee for the start and Bibee is 2-8 with a 4.03 ERA and 78 strikeouts this season. Erick Fedde will start for the White Sox and is 2-6 with a 4.46 ERA and 48 strikeouts this season.
The Cleveland Guardians come into this game looking to rebound from a 2-1 loss at the hands of the White Sox last time out to sit at 41-39 this season. After this series, the Guardians will head home for a series against the Seattle Mariners.
Entering Tuesday, Chase DeLauter has 63 hits with 12 doubles, 7 home runs and 34 RBIs while Steven Kwan has 50 hits with 8 doubles, a home run and 13 RBIs and Jose Ramirez has 64 hits with 18 doubles, 10 home runs and 33 RBIs this season. Brayan Rocchio has also added 69 hits with 12 doubles, 5 home runs and 33 RBIs this season while Angel Martinez has 54 hits with 11 doubles, 11 homers and 33 RBIs and Rhys Hoskins has added 32 hits with 12 doubles, 7 home runs and 27 RBIs. Daniel Schneemann has 43 hits with 9 doubles, 6 home runs and 26 RBIs this season.
The Chicago White Sox come into this game looking to add on to their win over Cleveland from Tuesday to improve to 41-37 on the year. After this series, the White Sox will take on the Kansas City Royals in a series at home.
Going into Tuesday’s game, Munetaka Murakami has 48 hits with 20 home runs and 41 RBIs while Miguel Vargas has 65 hits with 12 doubles, a triple, 16 home runs and 44 RBIs and Colson Montgomery has 59 hits with 13 doubles, 20 home runs and 45 RBIs. Luisangel Acuna has 28 hits and Tristan Peters has 56 hits with 17 doubles so far this season. Chase Meidroth also has 76 hits with 14 doubles, 6 home runs and 25 RBIs this year.
I’m backing the White Sox here. The White Sox have been finding ways to get it done in this series and now send out Erick Fedde, who isn’t my favorite option in this White Sox rotation, but he’s been far better at home this season. I’ve given Tanner Bibee the benefit of the doubt, but the fact is that the Guardians have only won 25% of his starts this season and continue to burn money with him as a starter. I’ll back Chicago here.