San Diego Padres (16-7) vs. Colorado Rockies (9-15) April 22, 2026 8:40 pm EDT The Line: Colorado Rockies +135 / San Diego Padres -155; Over/Under: 11.5 (Get latest betting odds)
The San Diego Padres and the Colorado Rockies meet Wednesday in MLB action from Coors Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Colorado Rockies prediction.
The San Diego Padres will start Walker Buehler for the start here and Buehler is 1-1 with a 4.58 ERA and 18 strikeouts this season. Tomoyuki Sugano will start for the Rockies here and is 1-1 with a 3.92 ERA and 15 strikeouts this season.
The San Diego Padres come into this game looking to add on to their 1-0 win over Colorado last time out to sit at 16-7 this season. After this series, the Padres will head on the road for a series against the Arizona Diamondbacks.
Entering Tuesday, Jackson Merrill has 19 hits with 6 doubles, 3 home runs and 13 RBIs while Ramon Laureano has 21 hits with 4 doubles, a triple, 4 home runs and 15 RBIs as well on the year. Fernando Tatis Jr. has 20 hits with 4 doubles and 12 RBIs and Xander Bogaerts has 21 hits with 2 doubles, 3 home runs and 14 RBIs. Manny Machado also has 13 hits with 2 doubles, 2 home runs and 10 RBIs as well on the year.
The Colorado Rockies come into this game looking to shake off their loss at the hands of the Padres in Tuesday’s opener to fall to 9-15 this season. After this series, the Rockies will head on the road for a series against the New York Mets.
Going into Tuesday, TJ Rumfield has 20 hits with a double, a triple, 3 home runs and 11 RBIs while Ezequiel Tovar has 19 hits with 8 doubles, a home run and 6 RBIs. Hunter Goodman’s added 19 hits with 4 doubles, 5 home runs and 8 RBIs and Jordan Beck has 7 RBIs as well on the year. Troy Johnston has 21 hits with 6 doubles, 2 home runs and 10 RBIs. Willi Castro also has 15 hits with 4 doubles, a home run and 8 RBIs.
I’m on the Padres here. I just think they’re playing the better baseball right now and while Walker Buehler is not the dominant ace level starter he once was, I still think he’s a quality option in this game that can give the Padres some solid innings before handing it off to the clearly better bullpen in this game. Give me the Padres here.