Chicago Cubs (18-12) vs. San Diego Padres (19-10) April 29, 2026 4:10 pm EDT The Line: San Diego Padres -105 / Chicago Cubs -115; Over/Under: 9 (Get latest betting odds)
In this article, we will formulate a Cubs vs Padres Prediction for this MLB matchup on Wednesday, April 29 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The San Diego Padres have a 19-10 record this season and are sitting in the second place of the NL West. They have a 10-5 home record and are coming off a 3-8 home loss against the Cubs. Their previous three games were a 9-7 home win against the Cubs, a 7-12 loss and a 6-4 win at home against the Diamondbacks.
The Padres have a .238 batting average this season, .312 OBP and .386 Slugging percentage. San Diego’s pitching staff has a 4.20 ERA and 1.30 WHIP. Xander Bogaerts is the team’s best hitter with a .286 batting average. Ramon Laureano leads the team in RBI with 18, and Xander Bogaerts adds a team‑high 5 home runs.
Matt Waldron (R) is the projected starting pitcher for the Padres, and he has a 0-1 record, 12.46 ERA and 2.31 WHIP.
The Chicago Cubs have a 18-12 record this season and are sitting in the second place of the NL Central. They have a 7-7 away record and are coming off an 8-3 road win against the Padres. Their previous three games were a 7-9 road loss against the Padres, a 0-6 and a 4-12 road loss against the Dodgers.
The Cubs have a .261 batting average this season, .353 OBP and .424 Slugging percentage. Chicago’s pitching staff has a 4.01 ERA and 1.20 WHIP. Nico Hoerner is the team’s best hitter with a .293 batting average, also leading the team in RBI with 26. Ian Happ adds a team‑high 7 home runs.
Jameson Taillon (R) is the projected starting pitcher for the Cubs, and he has a 1-1 record, 4.55 ERA and 1.30 WHIP.
Both teams are tied 5-5 in their last 10 meetings and are 2-2 in their last 4 meetings in San Diego.
In this Cubs vs Padres Prediction, the Cubs are coming as -115 road favorites. Both teams have split wins in this series in two high-scoring affairs with 16 and 11 total runs. Both pitchers in today’s matchup have been bad with a combined 17.01 ERA, with Taillon having given up 4+ runs in two of his last three starts and Waldron having given up 12 runs in his two starts. Chicago has the third-best offense in baseball and the Padres are better against righties, so I expect another high-scoring affair. Take the over 9 in this one.