Chicago Cubs (17-11) vs. San Diego Padres (18-9) April 27, 2026 9:40 pm EDT The Line: San Diego Padres 0.0001 / Chicago Cubs 0.0001; Over/Under: 0.0001 (Get latest betting odds)
In this article, we will formulate a Cubs vs Padres Prediction for this MLB matchup on Monday, April 27 th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The San Diego Padres have a 18-9 record this season and are sitting in the second place of the NL West. They have a 9-4 home record and are coming off a 7-12 home loss against the Diamondbacks. Their previous three games were a 6-4 home win against the Diamondbacks, a 10-8 win and a 3-8 loss on the road to the Rockies .
The Padres have a .235 batting average this season, .311 OBP and .382 Slugging percentage. San Diego’s pitching staff has a 3.96 ERA and 1.29 WHIP. Xander Bogaerts is the team’s best hitter with a .278 batting average. Ramon Laureano leads the team in RBI with 18, and Manny Machado adds a team‑high 4 home runs.
Randy Vasquez (R) is the projected starting pitcher for the Padres, and he has a 2-0 record, 1.88 ERA and 1.08 WHIP.
The Chicago Cubs have a 17-11 record this season and are sitting in the second place of the NL Central. They have a 6-6 away record and are coming off a 0-6 road loss to the Dodgers. Their previous three games were a 4-12 loss and a 6-4 win on the road to the Dodgers, and an 8-7 home win against the Phillies.
The Cubs have a .263 batting average this season, .354 OBP and .427 Slugging percentage. Chicago’s pitching staff has a 3.89 ERA and 1.19 WHIP. Nico Hoerner is the team’s best hitter with a .307 batting average, also leading the team in RBI with 23. Ian Happ adds a team‑high 7 home runs.
Matthew Boyd (L) is the projected starting pitcher for the Cubs, and he has a 1-1 record, 5.79 ERA and 1.14 WHIP.
Both teams are tied 5-5 in their last 10 meetings and the Padres are 2-1 in their last three meetings in San Diego.
In this Cubs vs Padres Prediction, the Cubs are coming as -115 road favorites. The Cubs got shutout by the Dodgers yesterday while the Padres blew a game in the late innings against the Dbacks in Mexico City, so both teams are in a weird spot. Both teams have top-12 bullpen ERA and are weaker against the opposing starter throw hand, with 7.5 runs/9 as the Padres are terrible against lefties. Boyd has a much better 3.72 expected ERA and Vasquez has been excellent for the Padres so far, so I expect a low-scoring affair. Take the under 8 runs.