Chicago Cubs (29-26) vs. Pittsburgh Pirates (29-26) May 27, 2026 6:40 pm EDT The Line: Pittsburgh Pirates 0.0001 / Chicago Cubs 0.0001; Over/Under: 8.5 (Get latest betting odds)
In this article, we will formulate a Cubs vs Pirates Prediction for this MLB matchup on Wednesday, May 27 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Pittsburgh Pirates have a 29-26 record this season and are sitting in the fourth place of the NL Central. They have a 15-13 home record and are coming off a 12-1 home win against the Cubs. They will face the Twins and the Astros next.
The Pirates have a .252 batting average this season, .333 OBP and .391 Slugging percentage. Pittsburgh’s pitching staff has a 3.74 ERA and 1.23 WHIP. Nick Gonzales is the team’s best hitter with a .304 batting average. Oneil Cruz leads the team in RBI with 35, while Brandon Lowe adds a team-high 13 home runs.
Bubba Chandler (R) is the projected starting pitcher for the Pirates, and he has a 1-6 record, 4.79 ERA and 1.47 WHIP.
The Chicago Cubs have a 29-26 record this season and are sitting in the fifth place of the NL Central. They have a 11-15 away record and are coming off a 1-12 road defeat against the Pirates. They will face the Cardinals and the Athletics next.
The Cubs have a .236 batting average this season, .333 OBP and .385 Slugging percentage. Chicago’s pitching staff has a 4.23 ERA and 1.24 WHIP. Alex Bregman is the team’s best hitter with a .259 batting average. Nico Hoerner leads the team in RBI with 31, while Ian Happ adds a team-high 10 home runs.
Jameson Taillon (R) is the projected starting pitcher for the Cubs, and he has a 2-4 record, 5.20 ERA and 1.27 WHIP.
The Pirates are 4-1 in their last 5 meetings against the Cubs and have won their last two meetings in Pitssburgh.
In this Cubs vs Pirates Prediction, the Pirates are coming as -115 home favorites. The Cubs’ downfall continues, as they are now 2-14 in their last 16 games and are putting Jameson Taillon on the mound, who has 12 earned runs in his last two starts. He also got torched in his previous start against the Pirates this season, giving up 6 runs and has been terrible on the road with a 6.04 road ERA. Chicago is dead last against righties in the past couple of weeks, so keep fading them until further notice. Take the Pirates in this one.