Cincinnati Reds (20-16) vs. Chicago Cubs (24-12) May 6, 2026 7:40 pm EDT The Line: Chicago Cubs -181 / Cincinnati Reds 149; Over/Under: 8 (Get latest betting odds)
In this article we will formulate a Cubs vs Reds prediction for this MLB game on Wednesday, May 6th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.
The Chicago Cubs are 24-12 this year after they won the first two games in this series by scores of 5-4 and 3-2. In game two, Chicago erased a 2-0 deficit and got the win in extra innings. The Cubs recorded eight hits and they committed one error in the game, while they were led by Busch, who went 3-4 with one home run and two RBIs. Taillon allowed five hits and two earned runs over 5.2 innings, while Rolison picked up the win in relief. Prior to this series, Chicago swept the Diamondbacks in three games and won two out of three against the Padres .
This season, Chicago has a 3.83 ERA with a 1.17 WHIP and a .227 opponent batting average, while they have scored 193 runs with a .258 batting average and a .352 on base percentage. Nico Hoerner has led the Cubs with four home runs and 27 RBIs, while Dansby Swanson has added six home runs and 24 RBIs. The projected starting pitcher for Chicago is Colin Rea, who is 4-1 with a 4.41 ERA and a 1.32 WHIP over 32.2 innings pitched this year.
The Cincinnati Reds are 20-16 this season after they lost game two by a score of 3-2 in extra innings. Cincinnati led 2-0 in the sixth inning, but they allowed a run in the seventh and eighth, before failing to score in the 10th for the loss. The Reds recorded six hits and they committed one error in the game, while they were led by Bleday, who went 1-4 with one home run and one RBI. Abbott allowed four hits and zero earned runs over 5.2 innings, while Moll picked up the loss in relief. Prior to this series, Cincinnati lost all three against the Pirates, but did win two out of three against the Rockies before that.
This season, Cincinnati has a 4.45 ERA with a 1.50 WHIP and a .253 opponent batting average, while they have scored 147 runs with a .218 batting average and a .303 on base percentage. Sal Stewart has led the Reds with nine home runs and 29 RBIs, while Elly De La Cruz has added 10 home runs and 25 RBIs. The projected starting pitcher for Cincinnati is Brady Singer, who is 2-2 with a 5.57 ERA and a 1.73 WHIP over 32.1 innings pitched this season.
Chicago comes into this matchup on a seven game winning streak and they continue to pile up wins at home. The Cubs are 16-5 at home this year, while the Reds are 10-8 on the road. Cincinnati has lost five games in a row and they have scored two runs or fewer in three of those five loss. The Reds are starting Singer, who has allowed 3+ earned runs in three of his last five starts, while Rea has allowed 2, 1, 6, and 3 earned runs in his last four outings. I know the Cubs are hot right now, but they were very lucky to win the first two games in this series, so I think there is some value with the Reds. Take Cincinnati to win here.