Chicago Cubs (29-17) vs. Chicago White Sox (23-22) May 17, 2026 2:10 pm EDT The Line: Chicago White Sox 119 / Chicago Cubs -143; Over/Under: 8.5 (Get latest betting odds)
In this article, we will formulate a Cubs vs White Sox Prediction for this MLB matchup on Sunday, May 17 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Chicago White Sox have a 23-22 record this season and are sitting in the second place of the AL Central. They have a 13-10 home record and are coming off a 8-3 win against the Cubs. They will face the Mariners and the Giants next.
The White Sox have a .234 batting average this season, .324 OBP and .409 Slugging percentage. Chicago’s pitching staff has a 4.32 ERA and 1.37 WHIP. Munetaka Murakami is the team’s best hitter with a .236 batting average, also leading the team in RBI with 32. Munetaka Murakami adds a team high 17 home runs.
Erick Fedde (R) is the projected starting pitcher for the White Sox, and he has a 0-4 record, 3.77 ERA and 1.16 WHIP.
The Chicago Cubs have a 29-17 record this season and are sitting in the first place of the NL Central. They have a 11-12 away record and are coming off a 8-3 loss against the White Sox. They will face the Mariners and the Giants next.
The Cubs have a .247 batting average this season, .341 OBP and .406 Slugging percentage. Chicago’s pitching staff has a 3.90 ERA and 1.19 WHIP. Nico Hoerner is the team’s best hitter with a .262 batting average, also leading the team in RBI with 29. Ian Happ adds a team high 10 home runs.
Colin Rea (R) is the projected starting pitcher for the Cubs, and he has a 4-2 record, 4.68 ERA and 1.42 WHIP.
The Cubs are 8-2 in their last 10 meetings against the White Sox and are 3-1 in their last 4 road meetings.
In this Cubs vs White Sox Prediction, the Cubs are coming as -140 road favorites. The White Sox won yesterday and they have the pitching edge today as Erick Fedde goes up against Colin Rea. Fedde has a 2.41 home ERA while Rea a terrible 6.55 road ERA and the White Sox have been hitting righties much better in the past couple of weeks, with the Cubs ranking just 22 nd in batting against right-handed pitching. I like the value with the home dog in this spot, so take the White Sox on the moneyline in this one.