Arizona Diamondbacks (28-24) vs. San Francisco Giants (22-31) May 25, 2026 5:05 pm EDT The Line: San Francisco Giants 0.0001 / Arizona Diamondbacks 0.0001; Over/Under: 7.5 (Get latest betting odds)
In this article, we will formulate a Diamondbacks vs Giants Prediction for this MLB matchup on Monday, May 25 th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The San Francisco Giants have a 22-31 record this season and are sitting in the fourth place of the NL West. They have a 12-13 home record and are coming off a 8-5 home win against the White Sox. They will face the Rockies and the Brewers next.
The Giants have a .247 batting average this season, .295 OBP and .387 Slugging percentage. San Francisco’s pitching staff has a 4.22 ERA and 1.34 WHIP. Luis Arraez is the team’s best hitter with a .320 batting average. Casey Schmitt leads the team in RBI with 29, adding a team-high 11 home runs.
Landen Roupp (R) is the projected starting pitcher for the Giants, and he has a 5-4 record, 3.27 ERA and 1.15 WHIP.
The Arizona Diamondbacks have a 28-24 record this season and are sitting in the third place of the NL West. They have a 10-14 away record and are coming off a 9-1 home win against the Rockies. They will face the Mariners and the Dodgers next.
The Diamondbacks have a .248 batting average this season, .313 OBP and .404 Slugging percentage. Arizona’s pitching staff has a 4.08 ERA and 1.25 WHIP. Ildemaro Vargas is the team’s best hitter with a .307 batting average, also leading the team in RBI with 32. Ketel Marte adds a team-high 8 home runs.
Merrill Kelly (R) is the projected starting pitcher for the Diamondbacks, and he has a 4-3 record, 5.71 ERA and 1.51 WHIP.
The Diamondbacks are 6-1 in their last 7 meetings against the Giants but are 1-2 in their last 3 visits in San Francisco. They swept their previous series at home by 3-0 wins and a combined 23-8 score.
In this Diamondbacks vs Giants Prediction, the Giants are coming as -140 home favorites. The Giants are coming off back-to-back wins where they scored a combined 18 runs and their offense is starting to get hot. They also have the pitching edge in this game as Landen Roupp goes up against a struggling Merrill Kelly for the Dbacks and the Giants have superior bullpen, ranking 7 th in the league. I also like the fact that the Giants got swept in their previous series against the Dbacks, so this is a nice revenge spot. Take the Giants on the moneyline in this one.