San Francisco Giants (62-88) vs. St. Louis Cardinals (74-76) September 14, 2026 7:45 pm EDT The Line: St. Louis Cardinals -144 / San Francisco Giants 119; Over/Under: 7.5 (Get latest betting odds)
In this article, we will formulate a Giants vs Cardinals Prediction for this MLB matchup on Monday, September 14 th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The St. Louis Cardinals have a 74-76 record this season and are sitting in the 4th place of the NL Central. They have a 36-39 home record and are coming off a 1-3 home loss against the White Sox. They will face the Nationals and the Pirates next.
The St. Louis Cardinals have a .243 batting average this season, .317 OBP and .385 Slugging percentage. St. Louis’s pitching staff has a 4.29 ERA and 1.35 WHIP. Alec Burleson is the team’s best hitter with a .283 batting average, leading the team in RBI with 109, while Jordan Walker adds a team-high 28 home runs.
Quinn Mathews (L) is the projected starting pitcher for the Cardinals, and he has a 1-3 record, 4.11 ERA and 1.50 WHIP.
The San Francisco Giants have a 62-88 record this season and are sitting in the 4th place of the NL West. They have a 26-49 away record and are coming off a 4-6 home loss against the Padres. They will face the Dodgers and the Twins next.
The San Francisco Giants have a .247 batting average this season, .308 OBP and .407 Slugging percentage. San Francisco’s pitching staff has a 4.38 ERA and 1.36 WHIP. Jung Hoo Lee is the team’s best hitter with a .276 batting average. Rafael Devers leads the team in RBI with 98 and adds a team-high 37 home runs.
Landen Roupp (R) is the projected starting pitcher for the Giants, and he has a 9-13 record, 4.00 ERA and 1.28 WHIP.
The Giants have won their last four meetings against the Cardinals but have lost their last two visits in Saint Louis.
In this Giants vs Cardinals Prediction, the Cardinals are coming as -130 home favorites. Both pitchers have been in good form, but they are both overachieving right now, as they both have a 4+ ERA this season. Both offenses have been scorching-hot, as they average 12.1 runs against the opposing starter throw hand combined in their last 10 games and as a result, they are 14-4 to the over in their last 18 games combined. The total is low based on the pitchers’ recent form, but I will take the over 7.5 in this one.