St. Louis Cardinals (72-73) vs. San Francisco Giants (60-85) September 8, 2026 9:45 pm EDT The Line: San Francisco Giants -113 / St. Louis Cardinals -106; Over/Under: 7.5 (Get latest betting odds)
The San Francisco Giants and St. Louis Cardinals do battle Tuesday in an MLB contest at Oracle Park. Here’s a Giants vs Cardinals Prediction. This article will include a Giants vs Cardinals Pick.
The St. Louis Cardinals are 72-73 this year and play the White Sox and Giants next. The St. Louis Cardinals are batting .244 on the season, with a .317 OBP and a .387 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.30 ERA and a 1.35 WHIP. Jordan Walker leads the St. Louis Cardinals with 157 hits and 100 RBI, while Alec Burleson and Ivan Herrera have combined for 293 hits and 168 RBI.
Quinn Mathews gets the ball for the St. Louis Cardinals, and he is 1-2 with a 4.38 ERA and 24 strikeouts this season. This will be Mathews’ first career game against the San Francisco Giants.
The San Francisco Giants are 60-85 on the year and play the Padres and Cardinals next. The San Francisco Giants are batting .248 on the season, have a .309 OBP, and have a .407 slugging percentage. The San Francisco Giants’ pitching staff has a 4.37 ERA and a 1.36 WHIP. Rafael Devers leads the San Francisco Giants with 142 hits and 92 RBI, while Jung Hoo Lee and Willy Adames have combined for 247 hits and 104 RBI.
Landen Roupp gets the ball for the San Francisco Giants, and he is 8-13 with a 4.17 ERA and 137 strikeouts this season. This will be Roupp’s second career game against the St. Louis Cardinals.
I’m looking at the over in this spot. Mathews has a 4.38 ERA and 1.58 WHIP on the season, and he’s allowed 12 runs in his last 24.2 innings. Roupp has a 4.17 ERA and 1.29 WHIP on the season, and he’s allowed 15 earned runs in his last 31 innings. Mathews has a 5.21 ERA on the road, and Roupp has a 4.04 ERA at home. We should see some fireworks in this contest. Give me the over.