Chicago White Sox (25-24) vs. San Francisco Giants (20-30) May 22, 2026 10:15 pm EDT The Line: San Francisco Giants -107 / Chicago White Sox -112; Over/Under: 7 (Get latest betting odds)
The Chicago White Sox and San Francisco Giants meet Friday in MLB action at Oracle Park. Here’s a Giants vs. White Sox Prediction. This article will include a Giants vs. White Sox Pick.
The Chicago White Sox are 25-24 on the year and play the Twins and Tigers next. The Chicago White Sox are batting. 235 on the season, have a .323 OBP, and have a .405 slugging percentage. The Chicago White Sox pitching staff has a 4.35 ERA and a 1.36 WHIP. Chase Meidroth leads the Chicago White Sox with 46 hits and 11 RBI, while Munetaka Murakami and Miguel Vargas have combined for 82 hits and 62 RBI.
Davis Martin gets the ball for the Chicago White Sox, and he is 6-1 with a 1.61 ERA and 59 strikeouts this season. This will be Martin’s second career game against the San Francisco Giants.
The San Francisco Giants are 20-30 on the year and play the Diamondbacks and Rockies next. The San Francisco Giants are batting. 244 on the season, have a .291 OBP, and have a .378 slugging percentage. The San Francisco Giants’ pitching staff has a 4.15 ERA and a 1.34 WHIP. Luis Arraez leads the San Francisco Giants with 59 hits and 17 RBI while Rafael Devers and Jung Hoo Lee have combined for 95 hits and 37 RBI.
Trevor McDonald gets the ball for the San Francisco Giants, and he is 2-0 with a 2.37 ERA and 17 strikeouts this season. This will be McDonald’s first career game against the Chicago White Sox.
McDonald has been strong through 19 innings with a 2.37 ERA and 1.00 WHIP, but it’s just 19 innings. Martin is far more trustworthy through 56 innings with a 1.61 ERA and 0.98 WHIP. Martin has allowed 13 hits and 2 runs in his last 19 innings. In 32.1 innings he has a 1.95 ERA and .228 allowed batting average. Martin is putting up CY Young caliber numbers. It feels like oddsmakers are still doubting the White Sox because they’re the White Sox but we’re 49 games into the season. It might be time to say this team is good. Decent? The Giants stink. Give me the White Sox and the pick ’em price.