Cleveland Guardians (14-12) vs. Toronto Blue Jays (10-14) April 24, 2026 7:07 pm EDT The Line: Toronto Blue Jays 0.0001 / Cleveland Guardians 0.0001; Over/Under: 0.0001 (Get latest betting odds)
In this article, we will formulate a Guardians vs Blue Jays Prediction for this MLB matchup on Friday, April 25 th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The Toronto Blue Jays have a 10-14 record this season and are sitting in the fourth place of the AL East. They have a 6-6 home record and are coming off a 3-7 road loss against the Angels. Their previous three games were a 4-2 and a 5-2 road win against the Angels, and a 10-4 road win against the Diamondbacks.
The Blue Jays have a .256 batting average this season, .317 OBP and .379 Slugging percentage. Toronto’s pitching staff has a 4.46 ERA and 1.32 WHIP. Vladimir Guerrero Jr. is the team’s best hitter with a .337 batting average, also leading the team in RBI with 12. Andres Gimenez adds a team‑high 3 home runs.
Max Scherzer (R) is the projected starting pitcher for the Blue Jays, and he has a 1-2 record, 7.16 ERA and 1.29 WHIP.
The Cleveland Guardians have a 14-12 record this season and are sitting in the first place of the AL Central. They have a 6-7 away record and are coming off a 0-2 home loss against the Astros. Their previous three games were an 8-5 home win and a 2-9 home loss against the Astros, and an 8-4 home win against the Orioles.
The Guardians have a .228 batting average this season, .318 OBP and .374 Slugging percentage. Cleveland’s pitching staff has a 4.00 ERA and 1.26 WHIP. Brayan Rocchio is the team’s best hitter with a .269 batting average, also leading the team in RBI with 15. Jose Ramirez adds a team‑high 6 home runs.
Gavin Williams (R) is the projected starting pitcher for the Guardians, and he has a 3-1 record, 2.12 ERA and 1.01 WHIP.
The Guardians are 6-3 in their last 9 meetings against the Blue Jays and are 2-1 in their last three visits in Toronto.
In this Guardians vs Blue Jays Prediction, the Guardians are coming as -130 road favorites. Max Scherzer takes the mound for the Jays and he has been struggling this season and both teams have bottom-8 bullpen ERA’s this season so the total of 7.5 feels too low. Both teams average 8.1 runs per game combined and the Guardians are 3-1 to the over in their last 4 games. Take the over 7.5 in this one.