Cleveland Guardians (82-75) vs. Boston Red Sox (84-73) September 23, 2026 7:00 pm EDT The Line: Boston Red Sox -133 / Cleveland Guardians 110; Over/Under: 7.5 (Get latest betting odds)
In this article, we will formulate a Guardians vs Red Sox Prediction for this MLB matchup on Wednesday, September 23 rd in the second game of this series. Let’s take a look at the prediction for this MLB matchup.
The Boston Red Sox have a 84-73 record this season and are sitting in the 3rd place of the AL East. They have a 38-38 home record and are coming off a 2-3 home loss against the Guardians. They will face the Cubs next.
The Boston Red Sox have a .246 batting average this season, .320 OBP and .401 Slugging percentage. Boston’s pitching staff has a 3.59 ERA and 1.24 WHIP. Ceddanne Rafaela is the team’s best hitter with a .282 batting average. Willson Contreras leads the team in RBI with 81, adding a team-high 27 home runs.
Sonny Gray (R) is the projected starting pitcher for the Red Sox, and he has a 17-5 record, 2.82 ERA and 1.16 WHIP.
The Cleveland Guardians have a 82-75 record this season and are sitting in the 1st place of the AL Central. They have a 41-35 away record and are coming off a 3-2 road win against the Red Sox. They will face the Royals next.
The Cleveland Guardians have a .239 batting average this season, .316 OBP and .377 Slugging percentage. Cleveland’s pitching staff has a 3.77 ERA and 1.26 WHIP. Chase DeLauter is the team’s best hitter with a .292 batting average. Brayan Rocchio leads the team in RBI with 70, while Angel Martinez adds a team-high 17 home runs.
Foster Griffin (L) is the projected starting pitcher for the Guardians, and he has a 15-5 record, 3.67 ERA and 1.19 WHIP.
The Red Sox are 6-3 in their last 9 meetings against the Guardians but have lost their last two home meetings.
In this Guardians vs Red Sox Prediction, the Red Sox are coming as -130 home favorites. I love the pitching in this matchup, as both starters have a combined 6.49 ERA and a sub-1.20 WHIP. They are both in a rough stretch so they are both in a bounce-back spot and yesterday’s game had just 5 total runs. Both bullpens have been excellent and Boston is 9-1 to the under in its last 10 games and the Guardians have scored just four runs in their last two games. Take the under 7.5 in this one.