Pittsburgh Pirates (33-28) vs. Houston Astros (27-35) June 3, 2026 8:10 pm EDT The Line: Houston Astros +129 / Pittsburgh Pirates -156; Over/Under: 8 (Get latest betting odds)
The Pittsburgh Pirates and the Houston Astros meet Wednesday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Pittsburgh Pirates vs. Houston Astros prediction.
The Pittsburgh Pirates will send out Paul Skenes for the start here and Skenes is 6-5 with a 2.89 ERA and 75 strikeouts this season. In his career, Skenes is 0-1 with a 1.29 ERA and 14 strikeouts against Houston. Spencer Arrighetti will start for Houston here and is 7-1 with a 1.34 ERA and 43 strikeouts this season. This will be Arrighetti’s first career start against the Pirates.
The Pittsburgh Pirates come into this game looking to add on to their 10-6 win over Houston from Tuesday’s matchup to sit at 33-28 this season. After this series, the Pirates will head on the road for a series against the Atlanta Braves.
Oneil Cruz has 62 hits including 10 doubles, 14 home runs and 44 RBIs while Ryan O’Hearn has 49 hits with 6 doubles, 8 home runs and 30 RBIs this season. Nick Gonzales has 63 hits with 9 doubles and 26 RBIs while Brandon Lowe has 55 hits with 12 doubles, 15 home runs and 40 RBIs and Bryan Reynolds has 58 hits with 12 doubles, 2 triples, 6 home runs and 38 RBIs as well this season.
The Houston Astros come into this game looking to bounce back from their loss at the hands of Pittsburgh on Tuesday to fall to 27-35 this season. After this series, the Astros will take on the Athletics in a series at home.
Yordan Alvarez has 67 hits with 12 doubles, 21 home runs and 42 RBIs while Christian Walker has 56 hits with 10 doubles, 16 home runs and 44 RBIs on the year. Jose Altuve’s chipped in 40 hits with 10 doubles, 4 home runs and 12 RBIs and Carlos Correa has 34 hits with 8 doubles, 3 home runs and 16 RBIs. Cam Smith also has 43 hits with 8 doubles, 6 home runs and 21 RBIs. Yainer Diaz also has 24 hits with 5 doubles, 2 home runs and 14 RBIs.
I’m on the Astros in this one. I think Paul Skenes is still the best pitcher in baseball, but the problem here is that Spencer Arrighetti has also quietly been putting together one of the best marks in baseball as well this year and the value for me is on the Astros. For as well as Skenes has been pitching, the Pirates are just 6-6 in his starts and I think Arrighetti matches here and gets the Astros the W at a nice price.