San Francisco Giants (42-59) vs. Kansas City Royals (42-60) July 22, 2026 2:10 pm EDT The Line: Kansas City Royals +100 / San Francisco Giants -120; Over/Under: 8.5 (Get latest betting odds)
The San Francisco Giants and the Kansas City Royals meet Wednesday in MLB action from Kauffman Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Kansas City Royals prediction.
The San Francisco Giants will start Landen Roupp here and Roupp is 7-8 with a 3.98 ERA and 106 strikeouts this season. Seth Lugo will start for Kansas City and is 3-6 with a 4.39 ERA and 89 strikeouts this season.
The San Francisco Giants come into this game looking to bounce back from a 3-2 loss at the hands of the Royals on Tuesday to sit at 42-59 this season. After this series, the Giants will head home for a game against the Los Angeles Angels.
Luis Arraez has 122 hits with 22 doubles, 7 triples and 36 RBIs while Willy Adames has 84 hits with 21 doubles, 17 home runs and 42 RBIs along with 112 strikeouts. Matt Chapman has 72 hits with 18 doubles, a triple, 7 home runs and 42 RBIs and Jung Hoo Lee has 104 hits with 21 doubles and 33 RBIs. Heliot Ramos has 65 hits with 13 doubles, 8 home runs and 29 RBIs this season. Rafael Devers also has 92 hits with 25 doubles, 20 home runs and 53 RBIs but also has 120 strikeouts this season.
The Kansas City Royals come into this game looking to add on to their win over San Francisco from Tuesday to sit at 42-60 this season. After this series, the Royals will will take to the road for a series against the Detroit Tigers.
Jac Caglianone has 87 hits with 17 doubles, 16 home runs, 37 RBIs and 2 triples while Bobby Witt Jr. has 103 hits with 22 doubles, 13 home runs and 39 RBIs and Vinnie Pasquantino’s added 60 hits with 10 doubles, 2 triples, 6 home runs and 32 RBIs on the year. Maikel Garcia also has 70 hits with 17 doubles, 3 home runs and 30 RBIs this season. Carter Jensen’s also chipped in 79 hits with 22 doubles, 13 home runs and 51 RBIs this season.
I’m on KC here. I just don’t trust Landen Roupp in this matchup. Roupp has had some decent starts as of late but a lot of them have come against teams not hitting right-handed pitching all that well. The Royals haven’t lit the world on fire offensively, but Lugo is better at home and I think that KC gets it done for the Sweep. Give me Kansas City.