Seattle Mariners (21-22) vs. Houston Astros (16-27) May 13, 2026 8:10 pm EDT The Line: Houston Astros 104 / Seattle Mariners -126; Over/Under: 9 (Get latest betting odds)
In this article, we will formulate a Mariners vs Astros Prediction for this MLB matchup on Wednesday, May 13 th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.
The Houston Astros have a 16-27 record this season and are sitting in the fifth place of the AL West. They have a 9-12 home record and are coming off a 2-10 loss at home against the Mariners. They will face the Rangers and the Twins next.
The Astros have a .255 batting average this season, .330 OBP and .421 Slugging percentage. Houston’s pitching staff has a 5.61 ERA and 1.59 WHIP. Yordan Alvarez is the team’s best hitter with a .308 batting average, also leading the team in RBI with 29 and adding a team‑high 13 home runs.
Lance McCullers Jr. (R) is the projected starting pitcher for the Astros, and he has a 2-3 record, 7.41 ERA and 1.50 WHIP.
The Seattle Mariners have a 21-22 record this season and are sitting in the second place of the AL West. They have a 9-11 away record and are coming off a 10-2 win on the road against the Astros. They will face the White Sox and the Padres next.
The Mariners have a .231 batting average this season, .320 OBP and .380 Slugging percentage. Seattle’s pitching staff has a 3.67 ERA and 1.22 WHIP. Randy Arozarena is the team’s best hitter with a .303 batting average. Luke Raley leads the team in RBI with 23, also adding a team‑high 8 home runs.
Bryce Miller (R) is the projected starting pitcher for the Mariners and last season he had a 4-6 record, 5.68 ERA and 1.41 WHIP.
The Mariners have won their last 9 meetings against the Astros and have won their last five visits in Houston. Over is 6-2 in their last 8 meetings.
In this Mariners vs Astros Prediction, the Mariners are coming as -125 road favorites. Bryce Miller will make his season debut for the Mariners after a terrible campaign last season and he will go up against Lance McCullers Jr. who has been bad this season, having given up at least three runs in each of his last six starts and was torched in his previous start against the Mariners this season. On top of that, the Astros have the worst bullpen in baseball and both teams are better against righties, with 9.8 runs/9 combined, so I expect a high-scoring affair. Take the over 9 in this one.