Seattle Mariners (8-11) vs. San Diego Padres (12-6) April 16, 2026 8:40 pm EDT The Line: San Diego Padres 100 / Seattle Mariners -120; Over/Under: 8 (Get latest betting odds)
The Seattle Mariners and San Diego Padres meet Thursday in MLB action at Petco Park. Here’s a Padres vs. Mariners Prediction. This article will include a Padres vs. Mariners Pick.
The Seattle Mariners are 8-11 on the year and play the Rangers and Athletics next. The Seattle Mariners are batting. 209 on the season, have a .319 OBP, and have a .340 slugging percentage. The Seattle Mariners pitching staff has a 3.24 ERA and a 1.08 WHIP. Randy Arozarena leads the Seattle Mariners with 20 hits and 7 RBI while Brendan Donovan and Luke Raley have combined for 35 hits and 20 RBI.
Luis Castillo gets the ball for the Seattle Mariners, and he is 0-0 with a 6.92 ERA and 14 strikeouts this season. Castillo is 3-3 with a 3.71 ERA and 55 strikeouts in his career against the San Diego Padres.
The San Diego Padres are 12-6 on the year and play the Rockies and Angels next. The San Diego Padres are batting. 236 on the season, have a .310 OBP, and have a .394 slugging percentage. The San Diego Padres pitching staff has a 3.42 ERA and a 1.23 WHIP. Ramon Laureano leads the San Diego Padres with 19 hits and 12 RBI, while Jackson Merrill and Xander Bogaerts have combined for 37 hits and 26 RBI.
Walker Buehler gets the ball for the San Diego Padres, and he is 0-1 with a 4.97 ERA and 11 strikeouts this season. Buehler is 1-1 with a 7.08 ERA and 19 strikeouts in his career against the Seattle Mariners.
We were on the Padres yesterday and there’s no reason to stop now. This team simply has some magic to them and the wins keep piling up. Last night’s win only adds to the confidence and it’s also going to be tough for the Mariners to get off the canvas after such a loss. Castillo was horrible in his last outing and it’s hard to get behind a 6.92 ERA and 1.77 WHIP through 13 innings. Another bad start or two and we might have to have a tough conversation about Castillo. Either way, I’m not stepping in front of this Padres team that’s sprinkled with fairy dust or whatever. Give me the Padres.