Tampa Bay Rays (17-11) vs. Cleveland Guardians (15-15) April 28, 2026 6:10 pm EDT The Line: Cleveland Guardians -136 / Tampa Bay Rays 113; Over/Under: 7.5 (Get latest betting odds)
In this article, we will formulate a Rays vs Guardians Prediction for this MLB matchup on Tuesday, April 28 th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.
The Cleveland Guardians have a 15-15 record this season and are sitting in the second place of the AL Central. They have an 8-6 home record and are coming off a 2-3 home defeat by the Rays. Their previous three games were a 2-4 loss, a 3-5 loss and an 8-6 win on the road against the Blue Jays.
The Guardians have a .230 batting average this season, .316 OBP and .378 Slugging percentage. Cleveland’s pitching staff has a 4.03 ERA and 1.25 WHIP. Angel Martinez is the team’s best hitter with a .276 batting average. Brayan Rocchio leads the team in RBI with 17, and Jose Ramirez adds a team‑high 6 home runs.
Tanner Bibee (R) is the projected starting pitcher for the Guardians, and he has a 0-3 record, 4.45 ERA and 1.45 WHIP.
The Tampa Bay Rays have a 17-11 record this season and are sitting in the second place of the AL East. They have a 9-7 away record and are coming off a 3-2 road win against the Guardians. They won their previous three games at home against the Twins by scores of 4-2, 6-1, and 6-2.
The Rays have a .256 batting average this season, .332 OBP and .391 Slugging percentage. Tampa Bay’s pitching staff has a 4.28 ERA and 1.24 WHIP. Yandy Diaz is the team’s best hitter with a .327 batting average. Jonathan Aranda leads the team in RBI with 24, and Junior Caminero adds a team‑high 8 home runs.
Nick Martinez (R) is the projected starting pitcher for the Rays, and he has a 1-1 record, 2.10 ERA and 1.10 WHIP.
The Guardians are 7-3 in their last 10 meetings against the Rays and are 4-2 in their last 6 meetings in Cleveland. Under is 7-2-1 in their last 10 meetings.
In this Rays vs Guardians Prediction, the Guardians are coming as -135 home favorites. The Rays have been red-hot with five consecutive wins and have the pitching advantage today, as Nick Martinez goes up against Tanner Bibee. Martinez has one earned run in three of his last four starts, while Bibee has 10 earned runs across his last three starts and gave up 7 runs in his two starts against the Rays last season. The Rays also have a better offense and are even better against righties, while the Guardians are weaker against right-handed pitching. Take the Rays on the moneyline for plus money in this one.