Boston Red Sox (4-8) vs. St. Louis Cardinals (7-5) April 10, 2026 8:15 pm EDT The Line: St. Louis Cardinals 123 / Boston Red Sox -149; Over/Under: 7.5 (Get latest betting odds)
In this article, we will formulate a Red Sox vs Cardinals Prediction for this MLB matchup on Friday, April 10 th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The St. Louis Cardinals have a 7-5 record this season and are sitting in the third place of the NL Central. They have a 4-2 home record and are coming off a 6-1 road win against the Nationals. Their previous three games were a 7-6 road win against the Nationals, a 6-9 road loss, and a 5-3 road win against the Tigers.
The Cardinals have a .226 batting average this season, .324 OBP and .361 Slugging percentage. St. Louis’ pitching staff has a 4.95 ERA and 1.52 WHIP. Jordan Walker is the team’s best hitter with a .295 batting average, also leading the team in RBI with 12 and adding a team-high 5 home runs.
Dustin May (R) is the projected starting pitcher for the Cardinals, and he has a 0-2 record, 15.95 ERA and 2.73 WHIP.
The Boston Red Sox have a 4-8 record this season and are sitting in the fifth place of the AL East. They have a 1-5 away record and are coming off a 5-0 home win against the Brewers. Their previous three games were a 3-2 home win against the Brewers, a 6-8 and a 6-8 home loss against the Padres.
The Red Sox have a .226 batting average this season, .310 OBP and .356 Slugging percentage. Boston’s pitching staff has a 4.19 ERA and 1.35 WHIP. Wilyer Abreu is the team’s best hitter with a .383 batting average, also leading the team in RBI with 9 and adding a team-high 3 home runs.
Connelly Early (L) is the projected starting pitcher for the Red Sox, and he has a 0-0 record, 2.89 ERA and 1.50 WHIP.
The Red Sox have won their last four meetings against the Cardinals but are 1-2 in their last three visits in Saint Louis.
In this Red Sox vs Cardinals Prediction, the Red Sox are coming as -149 road favorites. Both teams are coming off back-to-back wins but I don’t trust the Cardinals with Dustin May on the mound. He has been lit up this season with 13 earned runs in his two starts, while Early has been decent for Boston with a sub-3 ERA. On top of that, the Red Sox have a better bullpen, so I like the value with Boston in this spot. Take the Red Sox on the moneyline to get the job done in this one.