Boston Red Sox (78-65) vs. Baltimore Orioles (69-74) September 6, 2026 1:35 pm EDT The Line: Baltimore Orioles 118 / Boston Red Sox -142; Over/Under: 7.5 (Get latest betting odds)
In this article, we will formulate a Red Sox vs Orioles Prediction for this MLB matchup on Sunday, September 6 th in the fourth game of this series. Let’s take a look at the prediction for this MLB matchup.
The Baltimore Orioles have a 69-74 record this season and are sitting in the 5th place of the AL East. They have a 34-37 home record and are coming off a 0-5 home loss against the Red Sox. They will face the Guardians and the Blue Jays next.
The Baltimore Orioles have a .234 batting average this season, .316 OBP and .394 Slugging percentage. Baltimore’s pitching staff has a 4.16 ERA and 1.34 WHIP. Pete Alonso is the team’s best hitter with a .265 batting average, adding a team-high 94 RBI and a team-high 33 home runs.
Kyle Bradish (R) is the projected starting pitcher for the Orioles, and he has a 7-12 record, 4.01 ERA and 1.42 WHIP.
The Boston Red Sox have a 78-65 record this season and are sitting in the 3rd place of the AL East. They have a 43-31 away record and are coming off a 5-0 road win against the Orioles. They will face the Angels and the Royals next.
The Boston Red Sox have a .249 batting average this season, .323 OBP and .406 Slugging percentage. Boston’s pitching staff has a 3.62 ERA and 1.24 WHIP. Ceddanne Rafaela is the team’s best hitter with a .282 batting average. Willson Contreras leads the team in RBI with 79 and adds a team-high 26 home runs.
Payton Tolle (L) is the projected starting pitcher for the Red Sox, and he has a 8-6 record, 3.23 ERA and 1.10 WHIP.
The Red Sox are 5-1 in their last 6 meetings against the Orioles and have won their last four visits in Baltimore.
In this Red Sox vs Orioles Prediction, the Red Sox are coming as -130 road favorites. I like the Red Sox to keep rolling over a struggling Orioles team that is has lost five straight and has failed to score in back-to-back games. Tolle has been excellent on the road with a 2.59 ERA for the Red Sox and he has been the better pitching option than the shaky Kyle Bradish. On top of that, the Red Sox have the second-best bullpen ERA in baseball, so I like them to win this game in a very good price. Take the Red Sox in this one.