Boston Red Sox (76-65) vs. Baltimore Orioles (69-72) September 4, 2026 7:05 pm EDT The Line: Baltimore Orioles 100 / Boston Red Sox -120; Over/Under: 8.5 (Get latest betting odds)
In this article, we will formulate a Red Sox vs Orioles Prediction for this MLB matchup on Friday, September 4 th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.
The Baltimore Orioles have a 69-72 record this season and are sitting in the 5th place of the AL East. They have a 34-35 home record and are coming off a 5-6 home loss against the Red Sox. They will face the Guardians and the Blue Jays next.
The Baltimore Orioles have a .235 batting average this season, .317 OBP, and .396 slugging percentage. Baltimore’s pitching staff has a 4.18 ERA and 1.34 WHIP. Pete Alonso is the Orioles’ best hitter with a .269 batting average, while leading the team in RBI with 94, adding a team-high 33 home runs.
Shane Baz (R) is the projected starting pitcher for the Orioles, with a 5-14 record, 4.01 ERA, and 1.35 WHIP.
The Boston Red Sox have a 76-65 record this season and are sitting in the 3rd place of the AL East. They have a 41-31 road record and are coming off a 6-5 road win against the Orioles. They will face the Angels and the Royals next.
The Boston Red Sox have a .250 batting average this season, .323 OBP, and .408 slugging percentage. Boston’s pitching staff has a 3.67 ERA and 1.24 WHIP. Ceddanne Rafaela is the Red Sox’ best hitter with a .282 batting average. Willson Contreras leads the team in RBI with 79, adding a team-high 26 home runs.
Ranger Suarez (L) is the projected starting pitcher for the Red Sox, with a 5-4 record, 3.64 ERA, and 1.24 WHIP.
The Red Sox are 3-1 in their last 4 meetings against the Orioles and have won their last three visits in Baltimore.
In this Red Sox vs Orioles Prediction, the Red Sox are coming as -115 road favorites. I like the Orioles in a bounce-back spot as home dogs in this matchup. Suarez has been shaky at best, alternating quality starts with bad games, while Baz has been better at home with a 3.82 ERA for the Orioles. On top of that, Baltimore has been dominating lefties lately, with a .287 batting average and 8.8 runs per game in their last 10, while Boston’s bullpen has been terrible in that span, with a 6.53 ERA. Take the Orioles at home for plus money.