Cincinnati Reds (20-17) vs. Chicago Cubs (25-12) May 7, 2026 2:20 pm EDT The Line: Chicago Cubs -207 / Cincinnati Reds 169; Over/Under: 8.5 (Get latest betting odds)
In this article, we will formulate a Reds vs Cubs Prediction for this MLB matchup on Thursday, May 7 th in the fourth game of this series. Let’s take a look at the prediction for this MLB matchup.
The Chicago Cubs have a 25-12 record this season and are sitting in the first place of the NL Central. They have a 17-5 home record and are coming off a 7-6 win at home against the Reds. They will face the Rangers and the Braves next.
The Cubs have a .259 batting average this season, .352 OBP and .429 Slugging percentage. Chicago’s pitching staff has a 3.85 ERA and 1.18 WHIP. Nico Hoerner is the team’s best hitter with a .290 batting average, also leading the team in RBI with 27. Ian Happ adds a team‑high 9 home runs.
Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 3-2 record, 2.40 ERA and 0.85 WHIP.
The Cincinnati Reds have a 20-17 record this season and are sitting in the fifth place of the NL Central. They have a 10-9 away record and are coming off a 6-7 loss on the road against the Cubs. They will face the Astros and the Nationals next.
The Reds have a .219 batting average this season, .304 OBP and .385 Slugging percentage. Cincinnati’s pitching staff has a 4.48 ERA and 1.50 WHIP. Elly De La Cruz is the team’s best hitter with a .267 batting average, also leading the team in RBI with 28. Sal Stewart adds a team‑high 9 home runs.
Rhett Lowder (R) is the projected starting pitcher for the Reds, and he has a 3-2 record, 5.09 ERA and 1.39 WHIP.
The Cubs have won their last three meetings against the Reds, all in this series and have won their last four meetings in Chicago.
In this Reds vs Cubs Prediction, the Cubs are coming as -200 home favorites. The Cubs have been the hottest team in baseball with eight consecutive wins and are facing a struggling Reds team that has lost six straight. The Cubs have the pitching advantage as Imanaga goes up against a struggling Rhett Lowder who was torched in his last start with 8 earned runs, and they also have the second-best offense in baseball and a better bullpen. Take the Cubbies to keep rolling in this one and get away with another win.