Cincinnati Reds (57-61) vs. Chicago White Sox (61-57) August 12, 2026 7:40 pm EDT The Line: Chicago White Sox -139 / Cincinnati Reds 130; Over/Under: 9 (Get latest betting odds)
In this article, we will formulate a Reds vs White Sox Prediction for this MLB matchup on Wednesday, August 12 th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.
The Chicago White Sox have a 61-57 record this season and are sitting in 1st place in the AL Central. They have a 36-23 home record and are coming off a 4-5 home loss against the Reds. They will face the Tigers and the Cubs next.
The Chicago White Sox have a .236 batting average this season, a .316 OBP, and a .406 slugging percentage. The White Sox’ pitching staff has a 4.10 ERA and a 1.30 WHIP. Chase Meidroth leads the White Sox with a .274 batting average, Munetaka Murakami leads the team 26 home runs, and Miguel Vargas leads the team with a team-high 68 RBI.
Luis Castillo (R) is the projected starting pitcher for the White Sox, and he has a 3-9 record, a 5.30 ERA, and a 1.41 WHIP.
The Cincinnati Reds have a 57-61 record this season and are sitting in 4th place in the NL Central. They have a 28-30 away record and are coming off a 5-4 away win against the White Sox. They will face the Marlins and the Cardinals next.
The Cincinnati Reds have a .228 batting average this season, a .308 OBP, and a .396 slugging percentage. The Reds’ pitching staff has a 4.47 ERA and a 1.40 WHIP. Elly De La Cruz leads the Reds with a .271 batting average, while Sal Stewart leads the team with 25 home runs and a team-high 87 RBI.
Rhett Lowder (R) is the projected starting pitcher for the Reds, and he has a 4-7 record, a 5.26 ERA, and a 1.48 WHIP.
The Reds are 5-2 in their last 7 meetings against the White Sox and have won their last four visits in Chicago.
In this Reds vs White Sox Prediction, the White Sox are coming as -140 home favorites. I don’t like either pitcher in this matchup, as they both have a combined 10.56 ERA and Lowder has been even weaker on the road with a 7.71 road ERA. Yesterday’s game had 9 total runs and the White Sox are 6-2 to the over in their last 8 games. Take the over 9 in this one.