Pittsburgh Pirates (64-69) vs. San Diego Padres (71-61) August 25, 2026 9:40 pm EDT The Line: San Diego Padres -119 / Pittsburgh Pirates +111; Over/Under: 7.5 (Get latest betting odds)
The Pittsburgh Pirates and the San Diego Padres meet Tuesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Pittsburgh Pirates vs. San Diego Padres prediction.
The Pittsburgh Pirates will send out Paul Skenes for the start here and Skenes is 9-11 with a 3.95 ERA and 171 strikeouts this season. Michael King will start for San Diego and is 8-9 with a 3.38 ERA and 128 strikeouts this season.
The Pittsburgh Pirates come into this game looking to add on to their 3-2 win over the Padres last time out to sit at 64-69 this season. After this series, the Pirates will head on the road for a series against the St. Louis Cardinals.
Entering Monday, Oneil Cruz has 70 hits including 10 doubles, 16 home runs and 51 RBIs while Ryan O’Hearn has 97 hits with 15 doubles, 17 home runs and 69 RBIs this season. Nick Gonzales has 142 hits with 22 doubles and 55 RBIs while Brandon Lowe has 123 hits with 26 doubles, 27 home runs and 80 RBIs and Bryan Reynolds has 127 hits with 31 doubles, 2 triples, 15 home runs and 66 RBIs as well this season.
The San Diego Padres come into this game looking to bounce back from their loss to Pittsburgh last time out to sit at 71-61 on the year. After this series, the Padres will head on the road for a series against the Tampa Bay Rays.
Going into Monday, Jackson Merrill has 119 hits with 20 doubles, 21 home runs and 66 RBIs while Gavin Sheets has 74 hits with 15 doubles, 16 home runs and 46 RBIs as well on the year. Fernando Tatis Jr. has 146 hits with 27 doubles, 17 home runs and 67 RBIs and Xander Bogaerts has 93 hits with 13 doubles, 11 home runs and 47 RBIs. Manny Machado also has 103 hits with 20 doubles, 24 home runs and 72 RBIs as well on the year.
I’m on the Padres here. I know Paul Skenes is one of the best pitchers in baseball, but the Pirates have just fallen off this season and have not been able to back him up. San Diego normally does their best work against righties and I think they get to Skenes and back up King, who I think has been their ace this season. Give me the Padres.