St. Louis Cardinals (23-16) vs. San Diego Padres (23-16) May 10, 2026 4:10 pm EDT The Line: San Diego Padres -136 / St. Louis Cardinals +113; Over/Under: 8.5 (Get latest betting odds)
The St. Louis Cardinals and the San Diego Padres meet Sunday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. San Diego Padres prediction.
The St. Louis Cardinals will send out Kyle Leahy for the start here and Leahy is 4-3 with a 4.93 ERA and 27 strikeouts this season. This will be Leahy’s first career start against the Padres. Walker Buehler will start for the Padres here and is 2-2 with a 5.64 ERA and 29 strikeouts this season. In his last five starts against the Padres, Buehler is 3-0 with a 3.90 ERA and 35 strikeouts.
The St. Louis Cardinals come into this game looking to bounce back from a 4-2 loss at the hands of the Padres on Saturday to fall to 23-16 this season. After this series, the Cardinals will head on the road for a series against the Athletics.
Entering Saturday, Jordan Walker leads the Cardinals with 42 hits, 8 doubles, 10 home runs and 27 RBIs while Alec Burleson has 40 hits with 10 doubles, 6 home runs and 30 RBIs. JJ Wetherholt has 34 hits with 7 home runs and 20 RBIs while Ivan Herrera has 36 hits with 10 doubles, 4 home runs and 17 RBIs. Nolan Gorman has 28 hits with 5 home runs and 22 RBIs this season. Masyn Winn’s added 33 hits with 6 doubles and 16 RBIs and Nathan Church has 27 hits with 5 home runs and 16 RBIs this season.
The San Diego Padres come into this game looking to add on to Saturday’s win over the Cardinals to improve to 23-17 on the year. After this series, the Padres will head on the road for a set against the Milwaukee Brewers.
Going into Saturday, Jackson Merrill has 33 hits with 8 doubles, 4 home runs and 18 RBIs while Ramon Laureano has 29 hits with 4 doubles, 2 triples, 5 home runs and 19 RBIs as well on the year. Fernando Tatis Jr. has 34 hits with 5 doubles and 13 RBIs and Xander Bogaerts has 36 hits with 2 doubles, 7 home runs and 23 RBIs. Manny Machado also has 25 hits with 4 doubles, 5 home runs and 18 RBIs as well on the year.
I’m on the over in this game. I don’t trust either one of these starting pitchers here in all honesty as I think both are fadeworthy at this point and I think that the offenses on both sides have been hot enough that both starters are in trouble early here. I’m expecting some offensive fireworks to close out the set, so give me the over here.