Detroit Tigers (20-31) vs. Baltimore Orioles (21-29) May 22, 2026 7:15 pm EDT The Line: Baltimore Orioles -131 / Detroit Tigers 109; Over/Under: 8.5 (Get latest betting odds)
In this article, we will formulate a Tigers vs Orioles Prediction for this MLB matchup on Friday, May 22 nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
The Baltimore Orioles have a 21-29 record this season and are sitting in the fifth place of the AL East. They have a 12-12 home record and are coming off a 5-3 loss against the Rays. They will face the Rays and the Blue Jays next.
The Orioles have a .233 batting average this season, .314 OBP and .386 Slugging percentage. Baltimore’s pitching staff has a 4.97 ERA and 1.46 WHIP. Taylor Ward is the team’s best hitter with a .257 batting average. Pete Alonso leads the team in RBI with 28, while Gunnar Henderson adds a team-high 10 home runs.
Chris Bassitt (R) is the projected starting pitcher for the Orioles, and he has a 3-3 record, 5.44 ERA and 1.70 WHIP.
The Detroit Tigers have a 20-31 record this season and are sitting in the fifth place of the AL Central. They have a 7-19 away record and are coming off a 3-1 loss against the Guardians. They will face the Angels and the White Sox next.
The Tigers have a .235 batting average this season, .318 OBP and .372 Slugging percentage. Detroit’s pitching staff has a 3.96 ERA and 1.28 WHIP. Riley Greene is the team’s best hitter with a .326 batting average. Dillon Dingler leads the team in RBI with 29, adding a team-high 9 home runs.
Jack Flaherty (R) is the projected starting pitcher for the Tigers, and he has a 0-5 record, 5.77 ERA and 1.60 WHIP.
The Reds are 3-1 in their last 4 meetings against the Cardinals but are 1-2 in their last three visits in Cincinnati.
In this Tigers vs Orioles Prediction, the Orioles are coming as -130 home favorites. Both teams have been struggling as they are 1-5 and 1-9 in their last 6 and 10 games respectively and I don’t trust either pitcher in this matchup as they both have 5+ ERA and 1.60+ WHIP. Baltimore ranks 25 th in bullpen ERA and the total is set at just 8.5 runs when both pitchers have 4 earned runs across their last three starts combined. Take the over in this one.