Chicago White Sox (9-14) vs. Arizona Diamondbacks (13-10) April 22, 2026 9:40 pm EDT The Line: Arizona Diamondbacks -156 / Chicago White Sox 129; Over/Under: 9 (Get latest betting odds)
In this article, we will formulate a White Sox vs Diamondbacks Prediction for this MLB matchup on Wednesday, April 22 nd in the second game of this series. Let’s take a look at the prediction for this MLB matchup.
The Arizona Diamondbacks have a 13-10 record this season and are sitting in the third place of the NL West. They have a 7-4 home record and are coming off a 5-11 home loss against the White Sox. Their previous three games were a 4-10 home loss and a 6-2 home win against the Blue Jays, and an 8-5 road win against the Orioles.
The Diamondbacks have a .242 batting average this season, .297 OBP and .401 Slugging percentage. Arizona’s pitching staff has a 4.32 ERA and 1.30 WHIP. Corbin Carroll is the team’s best hitter with a .288 batting average, also leading the team in RBI with 16. Ketel Marte adds a team‑high 4 home runs.
Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has a 1-0 record, 1.96 ERA and 1.22 WHIP.
The Chicago White Sox have a 9-14 record this season and are sitting in the fourth place of the AL Central. They have a 6-8 away record and are coming off an 11-5 road win against the Diamondbacks. Their previous three games were a 7-4 road win, a 6-7 road loss, and a 9-2 road win against the Athletics.
The White Sox have a .218 batting average this season, .312 OBP and .376 Slugging percentage. Chicago’s pitching staff has a 4.84 ERA and 1.46 WHIP. Chase Meidroth is the team’s best hitter with a .253 batting average. Munetaka Murakami leads the team in RBI with 17, also adding a team‑high 9 home runs.
Anthony Kay (L) is the projected starting pitcher for the White Sox, and he has a 1-0 record, 2.60 ERA and 1.27 WHIP.
Both teams are tied 4-4 in their last 8 meetings and are 2-2 in their last four meetings in Arizona.
In this White Sox vs Diamondbacks Prediction, the Diamondbacks are coming as -150 home favorites. The White Sox won yesterday and have now back-to-back wins with 18 runs scored, while the Dbacks have dropped two straight, with 21 earned runs combined. Even though both pitchers are looking good so far, Chicago has the 28 th bullpen ERA in baseball and both teams are excellent against left-handed pitching, scoring 10.3 runs/9 against lefties and are 11-2 to the over in their last 13 games combined. Ride the hot bats and take the over 9.5 in this one.