Minnesota Twins (26-28) vs. Chicago White Sox (27-26) May 26, 2026 7:40 pm EDT The Line: Chicago White Sox -105 / Minnesota Twins -115; Over/Under: 7.5 (Get latest betting odds)
In this article we will formulate a White Sox vs Twins prediction for this MLB game on Tuesday, May 26th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.
The Chicago White Sox are 27-26 this year after they won game one by a score of 3-1 on Monday. Chicago tied the game at one in the bottom of the first inning and they scored two in the second, which was enough to get the win. The White Sox recorded six hits and they committed one error in the game, while they were led by Romo, who went 1-3 with one home run and two RBIs. Kay allowed five hits and one earned run over 6.0 innings for the win, while Dominguez picked up the save. Prior to this series, Chicago lost two out of three against the Giants and two out of three against the Mariners.
This season, Chicago has a 4.47 ERA with a 1.36 WHIP and a .242 opponent batting average, while they have scored 238 runs with a .232 batting average and a .322 on base percentage. Munetaka Murakami has led the White Sox with 18 home runs and 37 RBIs, while Colson Montgomery has added 13 home runs and 32 RBIs. The projected starting pitcher for Chicago is Sean Burke, who is 2-3 with a 4.08 ERA and a 1.21 WHIP over 53.0 innings pitched this year.
The Minnesota Twins are 26-28 this season after they lost game one by a score of 3-1 on Monday. Minnesota led 1-0 in the first inning, but they failed to score over the last eight innings for the loss. The Twins recorded seven hits in the game and they were led by Lee, who went 1-3 with one home run and one RBI. Matthews allowed five hits and three earned runs over 6.0 innings for the loss, while Woods Richardson threw the final two innings in relief. Prior to this series, Minnesota swept the Red Sox in three games and won two out of three against the Astros.
This season, Minnesota has a 4.18 ERA with a 1.31 WHIP and a .241 opponent batting average, while they have scored 249 runs with a .239 batting average and a .324 on base percentage. Byron Buxton has led the Twins with 16 home runs and 26 RBIs, while Josh Bell has added five home runs and 30 RBIs. The projected starting pitcher for Minnesota is Joe Ryan, who is 3-3 with a 3.02 ERA and a 0.97 WHIP over 56.2 innings pitched this season.
Minnesota had their winning streak snapped on Monday afternoon in game one, but they have won four of their last five games. The Twins are 11-14 on the road this year, while the White Sox are 15-10 at home. Chicago has lost three of their last five games and they have allowed 8+ runs in two of their last three. The White Sox are starting Burke, who has allowed 4+ earned runs in two of his last three starts, while Ryan has allowed one earned in three straight outings. Take the Twins on the road here.