LA Chargers (0-2) vs. Buffalo Bills (2-0) September 27, 2026 1:00 pm EDT The Line: Buffalo Bills -7; Over/Under: 50.5 (Get latest betting odds)
The Los Angeles Chargers and Buffalo Bills meet Sunday in NFL action at Highmark Stadium. Here’s a Bills vs. Chargers Prediction. This article will include a Bills vs. Chargers Pick.
The Los Angeles Chargers lost to the Cardinals and Raiders, and they play the Seahawks next. The Los Angeles Chargers haven’t started 0-3 since the 2017 season. Justin Herbert is completing 59.3 percent of his passes for 401 yards, 2 touchdowns, and 3 interceptions. Ladd McConkey and Tre’ Harris have combined for 190 receiving yards and 1 touchdown, while David Njoku has 6 receptions.
The Los Angeles Chargers’ ground game is averaging 104 yards per contest, and Omarion Hampton leads the way with 137 yards and 2 touchdowns. Defensively, Los Angeles is allowing 26 points and 349 yards per game. Derwin James Jr. leads the Los Angeles Chargers with 17 tackles, Khalil Mack has 1 sack, and Cam Hart has 1 interception.
The Buffalo Bills beat the Texans and Lions, and they play the Patriots next. The Bills look to start 3-0 for a third straight season. Josh Allen is completing 66.7 percent of his passes for 582 yards, 5 touchdowns, and 0 interceptions. Dalton Kincaid and DJ Moore have combined for 325 receiving yards and 2 touchdowns, while Khalil Shakir has 7 receptions.
The Buffalo Bills ground game is averaging 144.5 yards per contest, and James Cook III leads the way with 192 yards and 1 touchdown. Defensively, Buffalo is allowing 31 points and 368 yards per game. Terrel Bernard leads the Buffalo Bills with 17 tackles, Greg Rousseau has 4 sacks, and Deone Walker has 3 pass deflections.
The Chargers have been the most disappointing team in the league through two games, as there’s great talent on both sides of the ball, and they lost twice at home as big favorites. It’s to the point where the Chargers have to consider making changes. I highly doubt a trip across the country to play this hot Bills team flips the switch. The defense can’t get off the field, and Herbert looks broken under new OC Mike McDaniel. I expect a double-digit win from the Bills, as these Chargers are in awful form out of the gate, and it’s a shame because this is a Super Bowl contender if things were clicking.