Detroit Lions (1-0) vs. Buffalo Bills (1-0) September 17, 2026 8:15 pm EDT The Line: Buffalo Bills -4.5; Over/Under: 53.5 (Get latest betting odds)
The Detroit Lions and Buffalo Bills meet Thursday in NFL action at Highmark Stadium. Here’s a Bills vs. Lions Prediction. This article will include a Bills vs Lions Pick.
The Detroit Lions beat the Saints and play the Jets next. The Detroit Lions look to start 2-0 for the first time since the 2017 season. Jared Goff is completing 66.7 percent of his passes for 206 yards, 2 touchdowns, and 0 interceptions. Amon-Ra St. Brown and Sam LaPorta have combined for 115 receiving yards and 2 touchdowns, while Jameson Williams has 4 receptions.
The Detroit Lions ground game is averaging 165 yards per contest, and Jahmyr Gibbs leads the way with 156 yards and 2 touchdowns. Defensively, Detroit is allowing 30 points and 469 yards per game. D.J. Reed leads the Detroit Lions with 10 tackles, Aidan Hutchinson has 2 sacks, and Derrick Barnes has 1 interception.
The Buffalo Bills beat the Texans, and they play the Chargers next. The Bills look to start 2-0 for a third straight season. Josh Allen is completing 69 percent of his passes for 334 yards, 2 touchdowns, and 0 interceptions. Dalton Kincaid and DJ Moore have combined for 230 receiving yards and 1 touchdown, while Khalil Shakir has 4 receptions.
The Buffalo Bills ground game is averaging 86 yards per contest, and James Cook III leads the way with 57 yards on 13 carries. Defensively, Buffalo is allowing 31 points and 381 yards per game. Terrel Bernard leads the Buffalo Bills with 12 tackles, Greg Rousseau has 2 sacks, and Davison Igbinosun has 1 pass deflection.
We’re seeing defenses struggle across the league early in the season, and it has me looking at overs. That’s the case here as well with a quick turnaround. The Lions and Bills each topped 30 points last week, and that includes Buffalo averaging 7.9 yards per play against an elite Texans defense on the road. The Lions defense allowed 29 first downs at home to the Saints and was absolutely carved up by Tyler Shough. This feels like a back-and-forth, high-scoring game between two high-powered offenses. Give me the over.